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Muthiah Manoharan

Showing results (91-100 of 172) with videos related to

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Organic Letters|November 11, 2024
Improved <i>In Vivo</i> Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA ModificationsDhrubajyoti Datta, Pawan Kumar, Jayanta Kundu, et al.
Nucleic Acid Therapeutics|October 21, 2022
Efficient Downregulation of <i>Alk4</i> in Skeletal Muscle After Systemic Treatment with Conjugated siRNAs in a Mouse Model for Duchenne Muscular DystrophySarah Engelbeen, Svetlana Pasteuning-Vuhman, Joke Boertje-van der Meulen, et al.
ACS Chemical Biology|October 23, 2025
Synthesis and Biophysical Properties of 3'-Deoxy-β-d-apio-d-furanosyl Nucleic AcidsVictorio Jauregui-Matos, Dhrubajyoti Datta, Jayanta Kundu, et al.
Nucleic Acids Research|September 29, 2020
Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosineAtsushi Mikami, Namrata Erande, Shigeo Matsuda, et al.
Nature Medicine|February 22, 2005
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7Veit Hornung, Margit Guenthner-Biller, Carole Bourquin, et al.
ACS Chemical Biology|December 18, 2015
5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing ActivityIvan Zlatev, Donald J Foster, Jingxuan Liu, et al.
Chemical Communications (Cambridge, England)|April 8, 2025
Expanding the binding space of argonaute-2: incorporation of either <i>E</i> or <i>Z</i> isomers of 6'-vinylphosphonate at the 5' end of the antisense strand improves RNAi activityDhrubajyoti Datta, Jayanta Kundu, Patrick Miller, et al.
Nature|December 14, 2007
A viral microRNA functions as an orthologue of cellular miR-155Eva Gottwein, Neelanjan Mukherjee, Christoph Sachse, et al.
Antisense & Nucleic Acid Drug Development|September 5, 2003
Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivoLijiang Shen, Andrew Siwkowski, Edward V Wancewicz, et al.
Biochemistry|June 22, 2005
Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modificationsMartin Egli, George Minasov, Valentina Tereshko, et al.
Pageof 18

Showing results (91-100 of 172) with videos related to

Sort By:
Pageof 18
Organic Letters|November 11, 2024
Improved <i>In Vivo</i> Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA ModificationsDhrubajyoti Datta, Pawan Kumar, Jayanta Kundu, et al.
Nucleic Acid Therapeutics|October 21, 2022
Efficient Downregulation of <i>Alk4</i> in Skeletal Muscle After Systemic Treatment with Conjugated siRNAs in a Mouse Model for Duchenne Muscular DystrophySarah Engelbeen, Svetlana Pasteuning-Vuhman, Joke Boertje-van der Meulen, et al.
ACS Chemical Biology|October 23, 2025
Synthesis and Biophysical Properties of 3'-Deoxy-β-d-apio-d-furanosyl Nucleic AcidsVictorio Jauregui-Matos, Dhrubajyoti Datta, Jayanta Kundu, et al.
Nucleic Acids Research|September 29, 2020
Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosineAtsushi Mikami, Namrata Erande, Shigeo Matsuda, et al.
Nature Medicine|February 22, 2005
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7Veit Hornung, Margit Guenthner-Biller, Carole Bourquin, et al.
ACS Chemical Biology|December 18, 2015
5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing ActivityIvan Zlatev, Donald J Foster, Jingxuan Liu, et al.
Chemical Communications (Cambridge, England)|April 8, 2025
Expanding the binding space of argonaute-2: incorporation of either <i>E</i> or <i>Z</i> isomers of 6'-vinylphosphonate at the 5' end of the antisense strand improves RNAi activityDhrubajyoti Datta, Jayanta Kundu, Patrick Miller, et al.
Nature|December 14, 2007
A viral microRNA functions as an orthologue of cellular miR-155Eva Gottwein, Neelanjan Mukherjee, Christoph Sachse, et al.
Antisense & Nucleic Acid Drug Development|September 5, 2003
Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivoLijiang Shen, Andrew Siwkowski, Edward V Wancewicz, et al.
Biochemistry|June 22, 2005
Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modificationsMartin Egli, George Minasov, Valentina Tereshko, et al.
Pageof 18