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Muthiah Manoharan

Showing results (121-130 of 172) with videos related to

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Nucleic Acids Research|September 29, 2025
Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAsShohei Mori, Dhrubajyoti Datta, Lydia Perkins, et al.
Angewandte Chemie (International Ed. in English)|February 26, 2011
Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAsMuthiah Manoharan, Akin Akinc, Rajendra K Pandey, et al.
Molecular Therapy. Nucleic Acids|November 4, 2015
Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA QuantificationAmy Chan, Abigail Liebow, Makiko Yasuda, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|March 5, 2009
Development of lipidoid-siRNA formulations for systemic delivery to the liverAkin Akinc, Michael Goldberg, June Qin, et al.
Nature|September 28, 2007
Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathwayMatthias John, Rainer Constien, Akin Akinc, et al.
Journal of the American Chemical Society|August 3, 2022
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β-<i>C</i>-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target EffectsDale C Guenther, Shohei Mori, Shigeo Matsuda, et al.
Nature Biotechnology|May 23, 2018
Reversal of siRNA-mediated gene silencing in vivoIvan Zlatev, Adam Castoreno, Christopher R Brown, et al.
Molecular Therapy. Nucleic Acids|January 30, 2017
A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In VivoJustin B Lee, Kaixin Zhang, Yuen Yi C Tam, et al.
Chemical Communications (Cambridge, England)|April 13, 2019
5'-Morpholino modification of the sense strand of an siRNA makes it a more effective passengerPawan Kumar, Rubina G Parmar, Christopher R Brown, et al.
Nucleic Acids Research|July 30, 2015
Identification of siRNA delivery enhancers by a chemical library screenJerome Gilleron, Prasath Paramasivam, Anja Zeigerer, et al.
Pageof 18

Showing results (121-130 of 172) with videos related to

Sort By:
Pageof 18
Nucleic Acids Research|September 29, 2025
Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAsShohei Mori, Dhrubajyoti Datta, Lydia Perkins, et al.
Angewandte Chemie (International Ed. in English)|February 26, 2011
Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAsMuthiah Manoharan, Akin Akinc, Rajendra K Pandey, et al.
Molecular Therapy. Nucleic Acids|November 4, 2015
Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA QuantificationAmy Chan, Abigail Liebow, Makiko Yasuda, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|March 5, 2009
Development of lipidoid-siRNA formulations for systemic delivery to the liverAkin Akinc, Michael Goldberg, June Qin, et al.
Nature|September 28, 2007
Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathwayMatthias John, Rainer Constien, Akin Akinc, et al.
Journal of the American Chemical Society|August 3, 2022
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β-<i>C</i>-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target EffectsDale C Guenther, Shohei Mori, Shigeo Matsuda, et al.
Nature Biotechnology|May 23, 2018
Reversal of siRNA-mediated gene silencing in vivoIvan Zlatev, Adam Castoreno, Christopher R Brown, et al.
Molecular Therapy. Nucleic Acids|January 30, 2017
A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In VivoJustin B Lee, Kaixin Zhang, Yuen Yi C Tam, et al.
Chemical Communications (Cambridge, England)|April 13, 2019
5'-Morpholino modification of the sense strand of an siRNA makes it a more effective passengerPawan Kumar, Rubina G Parmar, Christopher R Brown, et al.
Nucleic Acids Research|July 30, 2015
Identification of siRNA delivery enhancers by a chemical library screenJerome Gilleron, Prasath Paramasivam, Anja Zeigerer, et al.
Pageof 18