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Muthiah Manoharan

Showing results (151-160 of 172) with videos related to

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Nature|November 13, 2004
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAsJürgen Soutschek, Akin Akinc, Birgit Bramlage, et al.
Experimental Neurology|November 29, 2011
Widespread suppression of huntingtin with convection-enhanced delivery of siRNADavid K Stiles, Zhiming Zhang, Pei Ge, et al.
Nucleic Acids Research|October 6, 2017
Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugatesJayaprakash K Nair, Husain Attarwala, Alfica Sehgal, et al.
Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis|April 2, 2016
Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosisJames S Butler, Amy Chan, Susete Costelha, et al.
Journal of Medicinal Chemistry|February 9, 2023
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC PathwaysPachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, et al.
Nucleic Acids Research|August 19, 2020
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugatesChristopher R Brown, Swati Gupta, June Qin, et al.
Journal of the American Chemical Society|August 28, 2023
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAsShigeo Matsuda, Saikat Bala, Jen-Yu Liao, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|May 13, 2010
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanismsAkin Akinc, William Querbes, Soma De, et al.
Nucleic Acids Research|May 14, 2024
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primatesMikyung Yu, June Qin, Xiumin Liu, et al.
Journal of the American Chemical Society|December 2, 2014
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencingJayaprakash K Nair, Jennifer L S Willoughby, Amy Chan, et al.
Pageof 18

Showing results (151-160 of 172) with videos related to

Sort By:
Pageof 18
Nature|November 13, 2004
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAsJürgen Soutschek, Akin Akinc, Birgit Bramlage, et al.
Experimental Neurology|November 29, 2011
Widespread suppression of huntingtin with convection-enhanced delivery of siRNADavid K Stiles, Zhiming Zhang, Pei Ge, et al.
Nucleic Acids Research|October 6, 2017
Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugatesJayaprakash K Nair, Husain Attarwala, Alfica Sehgal, et al.
Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis|April 2, 2016
Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosisJames S Butler, Amy Chan, Susete Costelha, et al.
Journal of Medicinal Chemistry|February 9, 2023
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC PathwaysPachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, et al.
Nucleic Acids Research|August 19, 2020
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugatesChristopher R Brown, Swati Gupta, June Qin, et al.
Journal of the American Chemical Society|August 28, 2023
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAsShigeo Matsuda, Saikat Bala, Jen-Yu Liao, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|May 13, 2010
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanismsAkin Akinc, William Querbes, Soma De, et al.
Nucleic Acids Research|May 14, 2024
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primatesMikyung Yu, June Qin, Xiumin Liu, et al.
Journal of the American Chemical Society|December 2, 2014
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencingJayaprakash K Nair, Jennifer L S Willoughby, Amy Chan, et al.
Pageof 18