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Muthiah Manoharan

Showing results (161-170 of 172) with videos related to

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Nucleic Acids Research|June 23, 2022
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilizationMark K Schlegel, Maja M Janas, Yongfeng Jiang, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|June 27, 2013
Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeuticsMartin A Maier, Muthusamy Jayaraman, Shigeo Matsuda, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|August 2, 2012
Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particlesTomoko Nakayama, James S Butler, Alfica Sehgal, et al.
Nature|March 28, 2006
RNAi-mediated gene silencing in non-human primatesTracy S Zimmermann, Amy C H Lee, Akin Akinc, et al.
Molecular Therapy. Nucleic Acids|January 25, 2013
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid CellsTatiana I Novobrantseva, Anna Borodovsky, Jamie Wong, et al.
Nature Medicine|April 8, 2015
An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophiliaAlfica Sehgal, Scott Barros, Lacramioara Ivanciu, et al.
Nature Biotechnology|April 29, 2008
A combinatorial library of lipid-like materials for delivery of RNAi therapeuticsAkin Akinc, Andreas Zumbuehl, Michael Goldberg, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|June 22, 2021
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <i>N</i>-Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to HumanRobin McDougall, Diane Ramsden, Sagar Agarwal, et al.
Proceedings of the National Academy of Sciences of the United States of America|August 13, 2008
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primatesMaria Frank-Kamenetsky, Aldo Grefhorst, Norma N Anderson, et al.
Nucleic Acids Research|March 2, 2019
Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugatesMaja M Janas, Ivan Zlatev, Ju Liu, et al.
Pageof 18

Showing results (161-170 of 172) with videos related to

Sort By:
Pageof 18
Nucleic Acids Research|June 23, 2022
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilizationMark K Schlegel, Maja M Janas, Yongfeng Jiang, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|June 27, 2013
Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeuticsMartin A Maier, Muthusamy Jayaraman, Shigeo Matsuda, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|August 2, 2012
Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particlesTomoko Nakayama, James S Butler, Alfica Sehgal, et al.
Nature|March 28, 2006
RNAi-mediated gene silencing in non-human primatesTracy S Zimmermann, Amy C H Lee, Akin Akinc, et al.
Molecular Therapy. Nucleic Acids|January 25, 2013
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid CellsTatiana I Novobrantseva, Anna Borodovsky, Jamie Wong, et al.
Nature Medicine|April 8, 2015
An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophiliaAlfica Sehgal, Scott Barros, Lacramioara Ivanciu, et al.
Nature Biotechnology|April 29, 2008
A combinatorial library of lipid-like materials for delivery of RNAi therapeuticsAkin Akinc, Andreas Zumbuehl, Michael Goldberg, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|June 22, 2021
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <i>N</i>-Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to HumanRobin McDougall, Diane Ramsden, Sagar Agarwal, et al.
Proceedings of the National Academy of Sciences of the United States of America|August 13, 2008
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primatesMaria Frank-Kamenetsky, Aldo Grefhorst, Norma N Anderson, et al.
Nucleic Acids Research|March 2, 2019
Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugatesMaja M Janas, Ivan Zlatev, Ju Liu, et al.
Pageof 18