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Molecular and Cellular Biology|January 24, 2007
Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domainZenshi Miyake, Mutsuhiro Takekawa, Qingyuan Ge, et al.
Molecular and Cellular Biology|September 10, 2009
Stimulus-specific distinctions in spatial and temporal dynamics of stress-activated protein kinase kinase kinases revealed by a fluorescence resonance energy transfer biosensorTaichiro Tomida, Mutsuhiro Takekawa, Pauline O'Grady, et al.
Nature Cell Biology|February 22, 2011
Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformationYuji Kubota, Pauline O'Grady, Haruo Saito, et al.
Science Signaling|October 18, 2012
The temporal pattern of stimulation determines the extent and duration of MAPK activation in a Caenorhabditis elegans sensory neuronTaichiro Tomida, Shigekazu Oda, Mutsuhiro Takekawa, et al.
FEBS Open Bio|February 13, 2023
Caspase 3-specific cleavage of MEK1 suppresses ERK signaling and sensitizes cells to stress-induced apoptosisHisashi Moriizumi, Yuji Kubota, Tomoyuki Tsuchiya, et al.
Science Advances|July 9, 2020
Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stressMoe Matsushita, Takanori Nakamura, Hisashi Moriizumi, et al.
Cancer Science|November 11, 2024
GADD45β-MTK1 signaling axis mediates oncogenic stress-induced activation of the p38 and JNK pathwaysSaeko Kawataki, Yuji Kubota, Kotoe Katayama, et al.
Plos Computational Biology|November 11, 2024
Molecular dynamics simulations of a multicellular model with cell-cell interactions and Hippo signaling pathwayToshihito Umegaki, Hisashi Moriizumi, Fumiko Ogushi, et al.
Nature Cell Biology|October 7, 2008
Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathwaysKyoko Arimoto, Hiroyuki Fukuda, Shinobu Imajoh-Ohmi, et al.
Molecular and Cellular Biology|June 8, 2002
Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 bindingHiroaki Mita, Junichiro Tsutsui, Mutsuhiro Takekawa, et al.
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