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Bioorganic & Medicinal Chemistry Letters|May 30, 2001
Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-IJ M Bergman, M T Abrams, J P Davide, et al.Bioorganic & Medicinal Chemistry Letters|April 11, 2001
2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferaseB W Trotter, A G Quigley, W C Lumma, et al.Bioorganic & Medicinal Chemistry Letters|March 7, 2001
Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferaseC J Dinsmore, J M Bergman, D D Wei, et al.Molecular and Cellular Biology|January 7, 1998
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosisR E Barrington, M A Subler, E Rands, et al.Cancer Research|December 26, 2001
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical modelsR B Lobell, C A Omer, M T Abrams, et al.British Journal of Pharmacology|September 25, 2009
Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemiaJ Tammam, C Ware, C Efferson, et al.Cancer Research|May 29, 2000
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitorC A Omer, Z Chen, R E Diehl, et al.Bioorganic & Medicinal Chemistry Letters|July 19, 2001
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferaseD C Beshore, I M Bell, C J Dinsmore, et al.Journal of Medicinal Chemistry|August 25, 2001
Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potencyI M Bell, S N Gallicchio, M Abrams, et al.Pageof 6