Showing results (1-10 of 148) with videos related to
Sort By:
Pageof 15
Cancer Chemotherapy and Pharmacology|January 1, 1994
Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classesN Osheroff, A H Corbett, S H Elsea, et al.Biochemistry|March 11, 1997
Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugsS H Elsea, M Westergaard, D A Burden, et al.The Journal of Biological Chemistry|July 5, 1992
Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeastS H Elsea, N Osheroff, J L NitissThe Journal of Biological Chemistry|January 27, 1995
A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticineS H Elsea, Y Hsiung, J L Nitiss, et al.The Journal of Biological Chemistry|September 1, 1995
A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitorsY Hsiung, S H Elsea, N Osheroff, et al.The Journal of Biological Chemistry|July 5, 1993
Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzymeA H Corbett, D Hong, N OsheroffThe Journal of Biological Chemistry|January 15, 1992
A role for the passage helix in the DNA cleavage reaction of eukaryotic topoisomerase II. A two-site model for enzyme-mediated DNA cleavageA H Corbett, E L Zechiedrich, N OsheroffBiochemistry|March 2, 1993
Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylationA H Corbett, A W Fernald, N OsheroffBiochemistry|April 13, 1993
Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase IIM J Robinson, A H Corbett, N OsheroffCancer Research|April 15, 1992
Phosphorylation of topoisomerase II by casein kinase II and protein kinase C: effects on enzyme-mediated DNA cleavage/religation and sensitivity to the antineoplastic drugs etoposide and 4'-(9-acridinylamino)methane-sulfon-m-anisidideR F DeVore, A H Corbett, N OsheroffPageof 15