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Bioorganic & Medicinal Chemistry Letters|April 9, 2013
Discovery of ML326: The first sub-micromolar, selective M5 PAMPatrick R Gentry, Thomas M Bridges, Atin Lamsal, et al.
Molecular Pharmacology|August 7, 2012
Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationshipsKaren J Gregory, Meredith J Noetzel, Jerri M Rook, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 4, 2013
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanismThomas M Bridges, Jerri M Rook, Meredith J Noetzel, et al.
Neuropharmacology|June 19, 2012
Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij ratsV D'Amore, I Santolini, C M van Rijn, et al.
Bioorganic & Medicinal Chemistry Letters|June 29, 2012
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptorJames M Salovich, Paige N Vinson, Douglas J Sheffler, et al.
American Journal of Physiology. Renal Physiology|December 15, 2015
Delayed treatment with PTBA analogs reduces postinjury renal fibrosis after kidney injuryNataliya I Skrypnyk, Subramaniam Sanker, Lauren Brilli Skvarca, et al.
Molecular Pharmacology|October 25, 2011
Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system functionMeredith J Noetzel, Jerri M Rook, Paige N Vinson, et al.
Bioorganic & Medicinal Chemistry Letters|May 22, 2012
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAMDouglas J Sheffler, Cody J Wenthur, Joshua A Bruner, et al.
Bioorganic & Medicinal Chemistry Letters|November 13, 2012
Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffoldAlice L Rodriguez, Ya Zhou, Richard Williams, et al.
Bioorganic & Medicinal Chemistry Letters|November 27, 2012
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophreniaUyen Le, Bruce J Melancon, Thomas M Bridges, et al.
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