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Bioorganic & Medicinal Chemistry Letters|June 26, 2014
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiencyMark Turlington, Meredith J Noetzel, Thomas M Bridges, et al.Journal of Medicinal Chemistry|September 21, 2013
Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254)Mark Turlington, Meredith J Noetzel, Aspen Chun, et al.The Laryngoscope|February 20, 2021
Multi-Institutional Analysis of Outcomes in Supraglottic Jet Ventilation with a Team-Based ApproachJennifer P Rodney, Justin R Shinn, Shaunak N Amin, et al.Biological Psychiatry|November 13, 2012
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activityJerri M Rook, Meredith J Noetzel, Wendy A Pouliot, et al.Bioorganic & Medicinal Chemistry Letters|September 18, 2012
Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossoverJason T Manka, Paige N Vinson, Karen J Gregory, et al.Molecular Pharmacology|October 7, 2010
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activityAlice L Rodriguez, Mark D Grier, Carrie K Jones, et al.Journal of Medicinal Chemistry|August 6, 2024
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine ReceptorJinming Li, Douglas L Orsi, Julie L Engers, et al.Bioorganic & Medicinal Chemistry Letters|October 18, 2015
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulatorsChrysa Malosh, Mark Turlington, Thomas M Bridges, et al.ACS Medicinal Chemistry Letters|July 10, 2015
Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting SchizophreniaSusana Conde-Ceide, Carlos M Martínez-Viturro, Jesús Alcázar, et al.Journal of Medicinal Chemistry|August 17, 2013
Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptorJosé Manuel Bartolomé-Nebreda, Susana Conde-Ceide, Francisca Delgado, et al.Pageof 10