Showing results (21-30 of 36) with videos related to
Sort By:
Pageof 4
Bioorganic & Medicinal Chemistry Letters|August 26, 2023
Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506Andrew G Cole, Steven G Kultgen, Nagraj Mani, et al.Journal of Medicinal Chemistry|November 10, 2009
In vitro and in vivo isotope effects with hepatitis C protease inhibitors: enhanced plasma exposure of deuterated telaprevir versus telaprevir in ratsFrançois Maltais, Young Chun Jung, Minzhang Chen, et al.Hepatology Communications|October 4, 2022
Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB-506 from Phase 1 studies in healthy subjects and those with hepatitis BMan-Fung Yuen, Elina Berliba, Wattana Sukeepaisarnjaroen, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b InhibitorsSimon Giroux, Jinwang Xu, T Jagadeeswar Reddy, et al.Antiviral Research|September 26, 2024
Preclinical and clinical antiviral characterization of AB-836, a potent capsid assembly modulator against hepatitis B virusAngela M Lam, Nagraj Mani, Andrzej Ardzinski, et al.Bioorganic & Medicinal Chemistry Letters|January 18, 2015
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkersSimon Giroux, Darius Bilimoria, Caroline Cadilhac, et al.Bioorganic & Medicinal Chemistry Letters|January 19, 2015
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: non-symmetric inhibitors with potent activity against genotype 1a and 1bSimon Giroux, Darius Bilimoria, Caroline Cadilhac, et al.Journal of Medicinal Chemistry|July 2, 2016
Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical ProfilesJohn J Court, Carl Poisson, Andrzej Ardzinski, et al.ACS Infectious Diseases|April 23, 2024
Discovery of <i>C</i>-Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2Eugen F Mesaros, Benjamin J Dugan, Min Gao, et al.Journal of Medicinal Chemistry|August 12, 2008
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationshipsPaul S Charifson, Anne-Laure Grillot, Trudy H Grossman, et al.Pageof 4