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Journal of Medicinal Chemistry|November 5, 2014
Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2Xiangqian Kong, Limin Chen, Lianying Jiao, et al.Journal of Medicinal Chemistry|October 12, 2017
Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell ProliferationChen Wang, Hao Jiang, Jia Jin, et al.Cell Reports|July 15, 2023
Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancerXiao Li, Fei Li, Fei Ye, et al.Nature Communications|June 3, 2024
PPIA dictates NRF2 stability to promote lung cancer progressionWeiqiang Lu, Jiayan Cui, Wanyan Wang, et al.Advanced Science (Weinheim, Baden-Wurttemberg, Germany)|January 13, 2022
Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising HemostasisJianhua Mao, Kongkai Zhu, Zhangbiao Long, et al.Science (New York, N.Y.)|February 26, 2016
Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasomeYuan Shi, Xiang Chen, Suzanne Elsasser, et al.European Journal of Medicinal Chemistry|June 20, 2021
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myelomaShuni Wang, Hong Yang, Mingbo Su, et al.Journal of Medicinal Chemistry|January 7, 2015
Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimizationLele Zhao, Yingqing Wang, Danyan Cao, et al.European Journal of Medicinal Chemistry|October 18, 2019
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitorsWenchao Lu, Jun Wang, Yong Li, et al.Journal of Medicinal Chemistry|June 2, 2021
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED InteractionDaohai Du, Dandan Xu, Licheng Zhu, et al.Pageof 10