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Bioorganic Chemistry|June 6, 2022
Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6-chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activitySujae Yang, Nam Gu Yoon, Min-A Park, et al.ACS Medicinal Chemistry Letters|July 16, 2021
Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog SelectivitySujae Yang, Nam Gu Yoon, Dongyoung Kim, et al.Bioorganic & Medicinal Chemistry Letters|December 17, 2019
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1Sejin Jung, Nam Gu Yoon, Sujae Yang, et al.Bioorganic Chemistry|June 27, 2020
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft modelsDarong Kim, So-Yeon Kim, Dongyoung Kim, et al.Journal of Medicinal Chemistry|November 21, 2024
Development of a Fluorescence Probe for High-Throughput Screening of Allosteric Inhibitors Targeting TRAP1Nam Gu Yoon, Danbi Choi, Ji Hye Lee, et al.Signal Transduction and Targeted Therapy|July 23, 2025
Pseudohypoxic stabilization of HIF1α via cyclophilin D suppression promotes melanoma metastasisHye-Kyung Park, Sung Hu, So Yeon Kim, et al.Advanced Science (Weinheim, Baden-Wurttemberg, Germany)|November 20, 2023
Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic RetinopathySo-Yeon Kim, Nam Gu Yoon, Jin Young Im, et al.Experimental & Molecular Medicine|January 21, 2020
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1Hye-Kyung Park, Nam Gu Yoon, Ji-Eun Lee, et al.Journal of the American Chemical Society|November 11, 2021
Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding SiteNam Gu Yoon, Hakbong Lee, So-Yeon Kim, et al.Journal of Medicinal Chemistry|February 19, 2020
Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting DrugSung Hu, Mariarosaria Ferraro, Ajesh P Thomas, et al.Pageof 1