Showing results (1-10 of 64) with videos related to
Sort By:
Pageof 7
Chemmedchem|August 8, 2006
Synthesis and pharmacological evaluation of 8- and 9-substituted benzolactam-v8 derivatives as potent ligands for protein kinase C, a therapeutic target for Alzheimer's diseaseUlrich R Mach, Nancy E Lewin, Peter M Blumberg, et al.Journal of Medicinal Chemistry|August 19, 2008
Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteinsSaïd El Kazzouli, Nancy E Lewin, Peter M Blumberg, et al.Tetrahedron Letters|October 8, 2016
Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKCMark E Petersen, Noemi Kedei, Nancy E Lewin, et al.Journal of Medicinal Chemistry|January 23, 2004
Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactonesHirokazu Tamamura, Dina M Sigano, Nancy E Lewin, et al.Journal of Medicinal Chemistry|May 28, 2004
Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligandsDehui Duan, Nancy E Lewin, Dina M Sigano, et al.Biochemistry|July 22, 2009
Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domainsMaria Soledad Sosa, Nancy E Lewin, Sung-Hee Choi, et al.Chembiochem : a European Journal of Chemical Biology|March 9, 2018
Deletion of the C26 Methyl Substituent from the Bryostatin Analogue Merle 23 Has Negligible Impact on Its Biological Profile and PotencyXiguang Zhao, Noemi Kedei, Alexandra Michalowski, et al.Bioconjugate Chemistry|December 24, 2010
Fluorescent-responsive synthetic C1b domains of protein kinase Cδ as reporters of specific high-affinity ligand bindingNami Ohashi, Wataru Nomura, Tetsuo Narumi, et al.Organic Letters|May 8, 2009
The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responsesGary E Keck, Wei Li, Matthew B Kraft, et al.Journal of Peptide Science : an Official Publication of the European Peptide Society|August 13, 2009
Synthesis of protein kinase Cdelta C1b domain by native chemical ligation methodology and characterization of its folding and ligand bindingNami Ohashi, Wataru Nomura, Mai Kato, et al.Pageof 7