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Molecules (Basel, Switzerland)|February 13, 2026
A Review on Farnesoid X Receptor (FXR) Modulators Focusing on Benzimidazole ScaffoldNaoki Teno, Keigo Gohda, Ko Fujimori
Chemical Biology & Drug Design|October 12, 2013
Synthetic substrates specific to activated plasmin can monitor the enzymatic functional status in situ in breast cancer cellsKeigo Gohda, Ko Fujimori, Naoki Teno, et al.
Molecules (Basel, Switzerland)|November 21, 2019
Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into OsteoblastsKo Fujimori, Yusuke Iguchi, Yukiko Yamashita, et al.
Molecules (Basel, Switzerland)|January 11, 2025
FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE2-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem CellsKo Fujimori, Yusuke Iguchi, Yukiko Yamashita, et al.
Bioorganic & Medicinal Chemistry Letters|April 11, 2021
Design and identification of a new farnesoid X receptor (FXR) partial agonist by computational structure-activity relationship analysis: Ligand-induced H8 helix fluctuation in the ligand-binding domain of FXR may lead to partial agonismKeigo Gohda, Yusuke Iguchi, Arisa Masuda, et al.
Bioorganic & Medicinal Chemistry|April 7, 2023
Discovery of FXR/PPARγ dual partial agonistYukiko Yamashita, Keigo Gohda, Yusuke Iguchi, et al.
Bioorganic & Medicinal Chemistry|July 4, 2020
N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR)Arisa Masuda, Keigo Gohda, Yusuke Iguchi, et al.
ACS Medicinal Chemistry Letters|March 19, 2021
Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in IleumNaoki Teno, Yusuke Iguchi, Keisuke Oda, et al.
ACS Medicinal Chemistry Letters|February 20, 2018
Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) AntagonistsNaoki Teno, Yukiko Yamashita, Yusuke Iguchi, et al.
Biological & Pharmaceutical Bulletin|July 16, 2025
FLG249 Exhibits FXR Antagonist Activity by Inducing Dissociation of Both Corepressors and Coactivators from FXRYusuke Iguchi, Yukiko Yamashita, Keigo Gohda, et al.
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