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Journal of Medicinal Chemistry
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August 20, 2010
Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury
Adrian Huang, Alessandro Moretto, Kristin Janz, et al.
Bioorganic & Medicinal Chemistry
|
August 1, 2007
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles
Neelu Kaila, Neal Green, Huan-Qiu Li, et al.
Journal of Medicinal Chemistry
|
August 27, 2025
Knowledge and Structure-Based Drug Design of 15-PGDH Inhibitors
Leela S Dodda, Sebastien Campos, David Ciccone, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
November 21, 2007
Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis
Patricia W Bedard, Valerie Clerin, Natalia Sushkova, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
September 29, 2021
Structural basis for isoform-specific inhibition of human CTPS1
Eric M Lynch, Michael A DiMattia, Steven Albanese, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 26, 2009
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood
Junjun Wu, Neal Green, Rajeev Hotchandani, et al.
Frontiers in Medicine
|
August 15, 2022
Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors
Diane L Rosin, J Perry Hall, Shuqiu Zheng, et al.
Thrombosis and Haemostasis
|
March 6, 2007
Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation
Daniel D Myers, Shirley K Wrobleski, Chris Longo, et al.
Journal of Medicinal Chemistry
|
August 25, 2007
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles
Neal Green, Yonghan Hu, Kristin Janz, et al.
Journal of Medicinal Chemistry
|
June 25, 2005
Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin
Neelu Kaila, William S Somers, Bert E Thomas, et al.
Page
of 4
Search research articles
Search
Showing results (21-30 of 35) with videos related to
Sort By:
Page
of 4
Journal of Medicinal Chemistry
|
August 20, 2010
Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury
Adrian Huang, Alessandro Moretto, Kristin Janz, et al.
Bioorganic & Medicinal Chemistry
|
August 1, 2007
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles
Neelu Kaila, Neal Green, Huan-Qiu Li, et al.
Journal of Medicinal Chemistry
|
August 27, 2025
Knowledge and Structure-Based Drug Design of 15-PGDH Inhibitors
Leela S Dodda, Sebastien Campos, David Ciccone, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
November 21, 2007
Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis
Patricia W Bedard, Valerie Clerin, Natalia Sushkova, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
September 29, 2021
Structural basis for isoform-specific inhibition of human CTPS1
Eric M Lynch, Michael A DiMattia, Steven Albanese, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 26, 2009
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood
Junjun Wu, Neal Green, Rajeev Hotchandani, et al.
Frontiers in Medicine
|
August 15, 2022
Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors
Diane L Rosin, J Perry Hall, Shuqiu Zheng, et al.
Thrombosis and Haemostasis
|
March 6, 2007
Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation
Daniel D Myers, Shirley K Wrobleski, Chris Longo, et al.
Journal of Medicinal Chemistry
|
August 25, 2007
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles
Neal Green, Yonghan Hu, Kristin Janz, et al.
Journal of Medicinal Chemistry
|
June 25, 2005
Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin
Neelu Kaila, William S Somers, Bert E Thomas, et al.
Page
of 4