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Journal of Medicinal Chemistry|April 18, 2019
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement PathwayRajeshri G Karki, James Powers, Nello Mainolfi, et al.Nature Medicine|November 13, 2023
IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trialLindsay Ackerman, Gerard Acloque, Sandro Bacchelli, et al.Journal of Medicinal Chemistry|February 6, 2018
The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular DegenerationChristopher M Adams, Karen Anderson, Gerald Artman, et al.Proceedings of the National Academy of Sciences of the United States of America|March 31, 2019
Small-molecule factor B inhibitor for the treatment of complement-mediated diseasesAnna Schubart, Karen Anderson, Nello Mainolfi, et al.Cancer Discovery|June 24, 2020
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH InhibitionBryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, et al.Journal of Medicinal Chemistry|February 20, 2020
Discovery of 4-((2<i>S</i>,4<i>S</i>)-4-Ethoxy-1-((5-methoxy-7-methyl-1<i>H</i>-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated DiseasesNello Mainolfi, Takeru Ehara, Rajeshri G Karki, et al.Pageof 3