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Bioorganic & Medicinal Chemistry Letters|February 7, 2012
Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinasesTao Wang, Michael A Block, Scott Cowen, et al.
Genes & Development|March 2, 2018
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of actionLorenzo I Finci, Xiaofeng Zhang, Xiuliang Huang, et al.
The Journal of Biological Chemistry|September 30, 2022
Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonistsSean Irwin, Craig Karr, Craig Furman, et al.
Journal of Medicinal Chemistry|December 23, 2016
Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 InhibitorsScott D Cowen, Daniel Russell, Leslie A Dakin, et al.
Biochemistry|July 5, 2023
Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening AssayMackenzie J Parker, Hyelee Lee, Shihua Yao, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in VivoJames E Dowling, Marat Alimzhanov, Larry Bao, et al.
ACS Medicinal Chemistry Letters|January 25, 2021
Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3Ryan A Brawn, Andrew Cook, Kiyoyuki Omoto, et al.
Cell Chemical Biology|February 5, 2020
Small Molecule Inhibition of CPS1 Activity through an Allosteric PocketShihua Yao, Tuong-Vi Nguyen, Alan Rolfe, et al.
Bioorganic & Medicinal Chemistry Letters|March 22, 2018
Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinasesLakshmaiah Gingipalli, Michael H Block, Larry Bao, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided HybridizationJames E Dowling, Claudio Chuaqui, Timothy W Pontz, et al.
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