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Molecular Therapy. Methods & Clinical Development|August 22, 2022
Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsidDavid Goertsen, Nick Goeden, Nicholas C Flytzanis, et al.Journal of Molecular Biology|July 1, 2014
Directed evolution of Gloeobacter violaceus rhodopsin spectral propertiesMartin K M Engqvist, R Scott McIsaac, Peter Dollinger, et al.Plos Genetics|August 31, 2011
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotypeIrina M Shapiro, Albert W Cheng, Nicholas C Flytzanis, et al.Nature Communications|September 16, 2014
Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neuronsNicholas C Flytzanis, Claire N Bedbrook, Hui Chiu, et al.Proceedings of the National Academy of Sciences of the United States of America|August 27, 2014
Directed evolution of a far-red fluorescent rhodopsinR Scott McIsaac, Martin K M Engqvist, Timothy Wannier, et al.Nature Neuroscience|December 10, 2021
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmosetDavid Goertsen, Nicholas C Flytzanis, Nick Goeden, et al.Nature Protocols|October 23, 2015
Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotypingJennifer B Treweek, Ken Y Chan, Nicholas C Flytzanis, et al.Nature Communications|May 2, 2020
Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulationJai Woong Seo, Elizabeth S Ingham, Lisa Mahakian, et al.Research Square|February 15, 2023
Intravenous functional gene transfer throughout the brain of non-human primates using AAVMiguel R Chuapoco, Nicholas C Flytzanis, Nick Goeden, et al.Nature Nanotechnology|July 10, 2023
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brainMiguel R Chuapoco, Nicholas C Flytzanis, Nick Goeden, et al.Pageof 1