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Nicholas D Smith

Showing results (41-50 of 61) with videos related to

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Bioorganic & Medicinal Chemistry Letters|September 27, 2005
3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonistsLida R Tehrani, Nicholas D Smith, Dehua Huang, et al.
Bioorganic & Medicinal Chemistry Letters|October 16, 2004
Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activityNicholas D Smith, Steve F Poon, Dehua Huang, et al.
Journal of Medicinal Chemistry|January 10, 2003
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activityNicholas D P Cosford, Lida Tehrani, Jeffrey Roppe, et al.
Journal of Medicinal Chemistry|September 3, 2004
Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activityJeffrey Roppe, Nicholas D Smith, Dehua Huang, et al.
Journal of Medicinal Chemistry|October 12, 2010
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain modelsJoseph E Payne, Céline Bonnefous, Kent T Symons, et al.
Bioorganic & Medicinal Chemistry Letters|December 22, 2009
Heterocycle-substituted proline dipeptides as potent VLA-4 antagonistsThomas S Reger, Jasmine Zunic, Nicholas Stock, et al.
Molecular Pharmacology|April 15, 2009
KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerizationKent T Symons, Mark E Massari, Phan M Nguyen, et al.
Bioorganic & Medicinal Chemistry Letters|December 21, 2011
Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitorsSergio G Durón, Andrew Lindstrom, Céline Bonnefous, et al.
Bioorganic & Medicinal Chemistry Letters|October 29, 2008
Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitorJoseph E Payne, Céline Bonnefous, Christian A Hassig, et al.
Bioorganic & Medicinal Chemistry Letters|October 29, 2008
Alpha-mercaptoketone based histone deacetylase inhibitorsPaul L Wash, Timothy Z Hoffman, Brandon M Wiley, et al.
Pageof 7

Showing results (41-50 of 61) with videos related to

Sort By:
Pageof 7
Bioorganic & Medicinal Chemistry Letters|September 27, 2005
3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonistsLida R Tehrani, Nicholas D Smith, Dehua Huang, et al.
Bioorganic & Medicinal Chemistry Letters|October 16, 2004
Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activityNicholas D Smith, Steve F Poon, Dehua Huang, et al.
Journal of Medicinal Chemistry|January 10, 2003
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activityNicholas D P Cosford, Lida Tehrani, Jeffrey Roppe, et al.
Journal of Medicinal Chemistry|September 3, 2004
Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activityJeffrey Roppe, Nicholas D Smith, Dehua Huang, et al.
Journal of Medicinal Chemistry|October 12, 2010
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain modelsJoseph E Payne, Céline Bonnefous, Kent T Symons, et al.
Bioorganic & Medicinal Chemistry Letters|December 22, 2009
Heterocycle-substituted proline dipeptides as potent VLA-4 antagonistsThomas S Reger, Jasmine Zunic, Nicholas Stock, et al.
Molecular Pharmacology|April 15, 2009
KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerizationKent T Symons, Mark E Massari, Phan M Nguyen, et al.
Bioorganic & Medicinal Chemistry Letters|December 21, 2011
Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitorsSergio G Durón, Andrew Lindstrom, Céline Bonnefous, et al.
Bioorganic & Medicinal Chemistry Letters|October 29, 2008
Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitorJoseph E Payne, Céline Bonnefous, Christian A Hassig, et al.
Bioorganic & Medicinal Chemistry Letters|October 29, 2008
Alpha-mercaptoketone based histone deacetylase inhibitorsPaul L Wash, Timothy Z Hoffman, Brandon M Wiley, et al.
Pageof 7