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Nature Communications|June 5, 2019
Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutationsRichard W Birkinshaw, Jia-Nan Gong, Cindy S Luo, et al.Cell Death and Differentiation|March 25, 2022
BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cellsDiane Moujalled, Adam G Southon, Eiman Saleh, et al.Chemmedchem|March 29, 2014
Simplified silvestrol analogues with potent cytotoxic activityBill C Hawkins, Lisa M Lindqvist, Duong Nhu, et al.Cell Death & Disease|September 11, 2020
Defining the susceptibility of colorectal cancers to BH3-mimetic compoundsMing-Jie Luo, Michelle Palmieri, Chris D Riffkin, et al.Journal of Medicinal Chemistry|January 25, 2014
De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterizationRyan M Brady, Amelia Vom, Michael J Roy, et al.Nature Communications|November 23, 2021
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosisYanxiang Meng, Katherine A Davies, Cheree Fitzgibbon, et al.Bioorganic & Medicinal Chemistry Letters|April 6, 2005
2-Ethoxybenzoxazole as a bioisosteric replacement of an ethyl benzoate group in a human rhinovirus (HRV) capsid binderRenee N Brown, Rachel Cameron, David K Chalmers, et al.Cell Death & Disease|March 13, 2021
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumorsChristoph Grohmann, Francesca Walker, Mark Devlin, et al.Nature Chemical Biology|October 9, 2019
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosisMark F van Delft, Stephane Chappaz, Yelena Khakham, et al.Nature Microbiology|August 31, 2016
Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosisMary Speir, Kate E Lawlor, Stefan P Glaser, et al.Pageof 12