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Cell Death & Disease|April 2, 2022
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKLAnnette V Jacobsen, Catia L Pierotti, Kym N Lowes, et al.Nature Communications|May 29, 2026
The benchmarking and application of tag-degraders in vivo to validate therapeutic targetsCharlene M Magtoto, Stephen Mieruszynski, Hao Dong, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|June 15, 2017
ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor TypesAnderly C Chüeh, Janson W T Tse, Michael Dickinson, et al.Journal of Medicinal Chemistry|September 24, 2010
New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formationOula C Mansour, Benny J Evison, Brad E Sleebs, et al.Cell Death and Differentiation|February 4, 2023
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cellsZilu Wang, Huimin Hu, Luuk Heitink, et al.Antimicrobial Agents and Chemotherapy|April 15, 2009
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activityGeorgina A Holloway, William N Charman, Alan H Fairlamb, et al.Elife|November 3, 2016
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancerStephanie Berger, Erik Procko, Daciana Margineantu, et al.ACS Medicinal Chemistry Letters|June 6, 2014
An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human RhinovirusSusanne C Feil, Stephanie Hamilton, Guy Y Krippner, et al.The Biochemical Journal|April 28, 2023
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinaseCatia L Pierotti, Annette V Jacobsen, Christoph Grohmann, et al.Journal of Medicinal Chemistry|March 4, 2011
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activityBrad E Sleebs, Peter E Czabotar, Wayne J Fairbrother, et al.Pageof 12