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Nature Structural & Molecular Biology|September 7, 2023
Substrate binding and inhibition of the anion exchanger 1 transporterMichael J Capper, Shifan Yang, Alexander C Stone, et al.Proteins|October 28, 2003
Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modelingDonald Petrey, Zhexin Xiang, Christopher L Tang, et al.Nature Communications|October 15, 2024
Expanding drug targets for 112 chronic diseases using a machine learning-assisted genetic priority scoreRobert Chen, Áine Duffy, Ben O Petrazzini, et al.Bioorganic & Medicinal Chemistry Letters|September 15, 2016
LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substratesArik A Zur, Huan-Chieh Chien, Evan Augustyn, et al.American Journal of Human Genetics|November 11, 2021
Identification of discriminative gene-level and protein-level features associated with pathogenic gain-of-function and loss-of-function variantsCigdem Sevim Bayrak, David Stein, Aayushee Jain, et al.Proceedings of the National Academy of Sciences of the United States of America|November 7, 2022
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter DeficiencyMegan L Koleske, Gregory McInnes, Julia E H Brown, et al.Nucleic Acids Research|May 7, 2014
PredictProtein--an open resource for online prediction of protein structural and functional featuresGuy Yachdav, Edda Kloppmann, Laszlo Kajan, et al.Nature Genetics|January 3, 2024
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indicationsÁine Duffy, Ben Omega Petrazzini, David Stein, et al.Cancer Discovery|February 11, 2021
Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF SignalingChristos Adamopoulos, Tamer A Ahmed, Maxwell R Tucker, et al.Nature Communications|September 24, 2020
Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicityJ G Coen van Hasselt, Rayees Rahman, Jens Hansen, et al.Pageof 12