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British Journal of Pharmacology|January 19, 2012
Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survivalKeng Gat Lim, Alexander I Gray, Susan Pyne, et al.
Cellular Signalling|October 21, 2004
c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cellsCatherine M Waters, Michelle C Connell, Susan Pyne, et al.
Bioorganic & Medicinal Chemistry|April 2, 2013
Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activatorsZheng Liu, Neil MacRitchie, Susan Pyne, et al.
Medchemcomm|January 8, 2014
Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cellsHoe-Sup Byun, Susan Pyne, Neil Macritchie, et al.
Prostaglandins & Other Lipid Mediators|July 19, 2006
The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factorJaclyn S Long, Viswanathan Natarajan, Gabor Tigyi, et al.
ACS Medicinal Chemistry Letters|December 18, 2014
Crystal Structure of Sphingosine Kinase 1 with PF-543Jing Wang, Stefan Knapp, Nigel J Pyne, et al.
Oncotarget|March 3, 2016
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cellsMelissa McNaughton, Melissa Pitman, Stuart M Pitson, et al.
Cellular Signalling|November 11, 2003
Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cellsNoreen Akhtar Moughal, Catherine Waters, Balwinder Sambi, et al.
The Biochemical Journal|December 17, 2005
Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migrationJaclyn S Long, Kazuaki Yokoyama, Gabor Tigyi, et al.
Cellular Signalling|May 31, 2011
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cellsKeng Gat Lim, Chaode Sun, Robert Bittman, et al.
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