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British Journal of Haematology|June 17, 2004
Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t-AML/MDSLorna Fern, Monica Pallis, G Ian Carter, et al.
British Journal of Haematology|September 1, 2012
The multi-kinase inhibitor TG02 overcomes signalling activation by survival factors to deplete MCL1 and XIAP and induce cell death in primary acute myeloid leukaemia cellsMonica Pallis, Amina Abdul-Aziz, Francis Burrows, et al.
Blood|October 24, 2002
The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemiaClaire Seedhouse, Rowena Bainton, Michael Lewis, et al.
British Journal of Haematology|December 6, 2021
Therapy for isocitrate dehydrogenase 2 (IDH2)R172 -mutant acute myeloid leukaemiaDavid C Linch, Robert K Hills, Alan K Burnett, et al.
British Journal of Haematology|October 10, 2019
Analysis of the clinical impact of NPM1 mutant allele burden in a large cohort of younger adult patients with acute myeloid leukaemiaDavid C Linch, Robert K Hills, Alan K Burnett, et al.
Plos One|May 4, 2018
Early changes in rpS6 phosphorylation and BH3 profiling predict response to chemotherapy in AML cellsMartin Grundy, Thomas Jones, Liban Elmi, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|November 26, 2009
Impaired S-phase arrest in acute myeloid leukemia cells with a FLT3 internal tandem duplication treated with clofarabineClaire Seedhouse, Martin Grundy, Shili Shang, et al.
Experimental Hematology|October 10, 2007
P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitorsLaura Connelly-Smith, Joanne Pattinson, Martin Grundy, et al.
Biochemical Pharmacology|October 18, 2003
Induction of apoptosis without redox catastrophe by thioredoxin-inhibitory compoundsMonica Pallis, Tracey D Bradshaw, Andrew D Westwell, et al.
Plos One|January 4, 2018
Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profilingMartin Grundy, Claire Seedhouse, Thomas Jones, et al.
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