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Biomaterials|October 15, 2025
Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer painChloe J Peach, Nguyen Huu Tu, Parker K Lewis, et al.The Journal of Biological Chemistry|August 14, 2014
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4Peishen Zhao, TinaMarie Lieu, Nicholas Barlow, et al.The Journal of Physiology|November 25, 2006
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in miceAndrew D Grant, Graeme S Cottrell, Silvia Amadesi, et al.Nature Communications|February 4, 2022
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in miceFrancesco De Logu, Romina Nassini, Alan Hegron, et al.Biomaterials|October 17, 2024
PAR<sub>2</sub> on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451Divya Bhansali, Nguyen H Tu, Kenji Inoue, et al.Proceedings of the National Academy of Sciences of the United States of America|November 1, 2017
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmissionRebecca E Yarwood, Wendy L Imlach, TinaMarie Lieu, et al.Cell Host & Microbe|September 27, 2025
A Bacteroides fragilis protease activates host PAR<sub>2</sub> to induce intestinal pain and inflammationMarkus Lakemeyer, Rocco Latorre, Kristyna Blazkova, et al.Proceedings of the National Academy of Sciences of the United States of America|February 3, 2022
Mice expressing fluorescent PAR<sub>2</sub> reveal that endocytosis mediates colonic inflammation and painRocco Latorre, Alan Hegron, Chloe J Peach, et al.Biomaterials|May 9, 2022
Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic painRocco Latorre, Paulina D Ramírez-Garcia, Alan Hegron, et al.American Journal of Physiology. Gastrointestinal and Liver Physiology|August 13, 2016
Legumain is activated in macrophages during pancreatitisLaura E Edgington-Mitchell, Thomas Wartmann, Alicia K Fleming, et al.Pageof 19