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Cancers|September 28, 2021
Cathepsin S Evokes PAR<sub>2</sub>-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse ModelsNguyen Huu Tu, Kenji Inoue, Elyssa Chen, et al.
Gut|March 31, 2021
Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effectsNestor Nivardo Jiménez-Vargas, Yang Yu, Dane D Jensen, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|November 11, 2020
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2Nguyen Huu Tu, Dane D Jensen, Bethany M Anderson, et al.
The Journal of Biological Chemistry|January 30, 2021
A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomesQuynh N Mai, Priyank Shenoy, Tim Quach, et al.
Proceedings of the National Academy of Sciences of the United States of America|October 7, 2025
Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesiaShavonne L Teng, Rocco Latorre, Divya Bhansali, et al.
Nature Communications|September 25, 2025
Targeting prostaglandin E<sub>2</sub> receptor 2 in Schwann cells inhibits inflammatory pain but not inflammationRomina Nassini, Lorenzo Landini, Matilde Marini, et al.
Hepatology (Baltimore, Md.)|October 2, 2015
Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarumShadi Abu-Hayyeh, Caroline Ovadia, TinaMarie Lieu, et al.
Cellular and Molecular Gastroenterology and Hepatology|March 17, 2024
Protease-Induced Excitation of Dorsal Root Ganglion Neurons in Response to Acute Perturbation of the Gut Microbiota Is Associated With Visceral and Somatic HypersensitivityCorey C Baker, Jessica L Sessenwein, Hannah M Wood, et al.
Proceedings of the National Academy of Sciences of the United States of America|June 18, 2020
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory painNestor N Jimenez-Vargas, Jing Gong, Matthew J Wisdom, et al.
Science Translational Medicine|June 2, 2017
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain reliefDane D Jensen, TinaMarie Lieu, Michelle L Halls, et al.
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