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Journal of Alzheimer'S Disease : JAD|July 23, 2026
Do anti-amyloid therapies demonstrate clinically meaningful benefit? A Bayesian reappraisalTommaso Costa, Stefano L Sensi, Poul F Høilund-Carlsen, et al.The EMBO Journal|June 12, 2004
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutationsLia Baki, Junichi Shioi, Paul Wen, et al.Brain : a Journal of Neurology|August 12, 2025
Restoring amyloid-β42 and γ-secretase function in Alzheimer's diseaseAlberto J Espay, Kariem Ezzat, Kasper P Kepp, et al.Biorxiv : the Preprint Server for Biology|May 25, 2026
PS FAD mutants and γ-secretase inhibition accumulate VEGFR2-derived peptide VCTF1 suppressing brain VEGFR2 dimerization, angiogenesis and neuroprotectionRukmani Pandey, Amira Zarrouk, Poulomi Dey, et al.Pflugers Archiv : European Journal of Physiology|November 26, 2010
Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activationIoannis E Michailidis, Radda Rusinova, Anastasios Georgakopoulos, et al.Proceedings of the National Academy of Sciences of the United States of America|September 16, 2015
Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesisLi Zhu, Minghao Zhong, Gregory A Elder, et al.Brain Research Bulletin|June 27, 2009
The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cellsLorenza Eder-Colli, Noelia Abad-Estarlich, Carine Pannetier, et al.FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology|September 1, 2017
Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15Qian Huang, Georgios Voloudakis, Yimin Ren, et al.The Journal of Biological Chemistry|September 26, 2003
Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activityWeiping Qin, Lap Ho, Patrick N Pompl, et al.Neurobiology of Aging|April 6, 2012
Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptorsGael Barthet, Julie Dunys, Zhiping Shao, et al.Pageof 6