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Nobuko Nishimura

Showing results (11-20 of 18) with videos related to

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Journal of Medicinal Chemistry|May 27, 2011
Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivativesNobuko Nishimura, Aaron Siegmund, Longbin Liu, et al.
Bioorganic & Medicinal Chemistry Letters|April 26, 2011
3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammationJian Jeffrey Chen, Thomas Nguyen, Derin C D'Amico, et al.
Journal of Medicinal Chemistry|March 14, 2022
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical ProbeNuria A Tamayo, Matthew P Bourbeau, Jennifer R Allen, et al.
Journal of Medicinal Chemistry|January 11, 2014
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profilesDavid J St Jean, Kate S Ashton, Michael D Bartberger, et al.
Journal of Medicinal Chemistry|November 10, 2015
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational ConstraintLewis D Pennington, Michael D Bartberger, Michael D Croghan, et al.
Journal of Medicinal Chemistry|May 3, 2012
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinasesAdrian L Smith, Noel D D'Angelo, Yunxin Y Bo, et al.
Journal of Medicinal Chemistry|August 18, 2012
Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511Mark H Norman, Kristin L Andrews, Yunxin Y Bo, et al.
Journal of Medicinal Chemistry|December 11, 2019
Discovery of a Covalent Inhibitor of KRAS<sup>G12C</sup> (AMG 510) for the Treatment of Solid TumorsBrian A Lanman, Jennifer R Allen, John G Allen, et al.
Pageof 2

Showing results (11-20 of 18) with videos related to

Sort By:
Pageof 2
You have reached the last page of results.This site can display upto 18 results.
Journal of Medicinal Chemistry|May 27, 2011
Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivativesNobuko Nishimura, Aaron Siegmund, Longbin Liu, et al.
Bioorganic & Medicinal Chemistry Letters|April 26, 2011
3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammationJian Jeffrey Chen, Thomas Nguyen, Derin C D'Amico, et al.
Journal of Medicinal Chemistry|March 14, 2022
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical ProbeNuria A Tamayo, Matthew P Bourbeau, Jennifer R Allen, et al.
Journal of Medicinal Chemistry|January 11, 2014
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profilesDavid J St Jean, Kate S Ashton, Michael D Bartberger, et al.
Journal of Medicinal Chemistry|November 10, 2015
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational ConstraintLewis D Pennington, Michael D Bartberger, Michael D Croghan, et al.
Journal of Medicinal Chemistry|May 3, 2012
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinasesAdrian L Smith, Noel D D'Angelo, Yunxin Y Bo, et al.
Journal of Medicinal Chemistry|August 18, 2012
Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511Mark H Norman, Kristin L Andrews, Yunxin Y Bo, et al.
Journal of Medicinal Chemistry|December 11, 2019
Discovery of a Covalent Inhibitor of KRAS<sup>G12C</sup> (AMG 510) for the Treatment of Solid TumorsBrian A Lanman, Jennifer R Allen, John G Allen, et al.
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