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ACS Medicinal Chemistry Letters|October 24, 2017
Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein DegradationKenichiro Shimokawa, Norihito Shibata, Tomoya Sameshima, et al.Cancer Science|May 31, 2017
Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligandsNorihito Shibata, Naoki Miyamoto, Katsunori Nagai, et al.Journal of Medicinal Chemistry|June 23, 2006
Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonistsTakashi Imada, Nobuo Cho, Toshihiro Imaeda, et al.Bioorganic & Medicinal Chemistry|May 24, 2017
2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinaseOsamu Kurasawa, Misaki Homma, Yuya Oguro, et al.Scientific Reports|September 12, 2018
Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinaseNorihito Shibata, Kenichiro Shimokawa, Katsunori Nagai, et al.Journal of Medicinal Chemistry|June 9, 2017
Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein LigandsNorihito Shibata, Katsunori Nagai, Yoko Morita, et al.Biochemical and Biophysical Research Communications|February 4, 2017
K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technologyKotaro Sakamoto, Yusuke Kamada, Tomoya Sameshima, et al.Bioorganic & Medicinal Chemistry|March 13, 2017
Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-onesOsamu Kurasawa, Yuya Oguro, Tohru Miyazaki, et al.Bioorganic & Medicinal Chemistry|May 20, 2022
New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moietyNobuo Cho, Ko Kikuzato, Yushi Futamura, et al.Journal of Medicinal Chemistry|August 17, 2023
Second-Generation AUTACs for Targeted Autophagic DegradationDaiki Takahashi, Taiichi Ora, Shigekazu Sasaki, et al.Pageof 3