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Journal of Medicinal Chemistry|November 13, 2013
Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteinsYuta Tanaka, Katsuji Aikawa, Goushi Nishida, et al.Journal of Medicinal Chemistry|January 3, 2020
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor AgentOsamu Kurasawa, Tohru Miyazaki, Misaki Homma, et al.The Journal of Biological Chemistry|February 4, 2017
In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)Nobumichi Ohoka, Keiichiro Okuhira, Masahiro Ito, et al.The Journal of Biological Chemistry|March 17, 2018
Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradationNobumichi Ohoka, Yoko Morita, Katsunori Nagai, et al.Science Advances|May 28, 2019
Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitorKenichi Iwai, Tadahiro Nambu, Ryo Dairiki, et al.Journal of Medicinal Chemistry|August 26, 2021
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious AntimalarialsBenoît Laleu, Yuichiro Akao, Atsuko Ochida, et al.Pageof 3