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Journal of Medicinal Chemistry|March 16, 2017
Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast CancerHeather E Burks, Tinya Abrams, Christina A Kirby, et al.Journal of Medicinal Chemistry|November 14, 2024
Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell DiseaseJohn Ryan Kerrigan, Noel M Thomsen, Artiom Cernijenko, et al.Journal of Medicinal Chemistry|March 23, 2018
Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast CancerGeorge S Tria, Tinya Abrams, Jason Baird, et al.Journal of Medicinal Chemistry|January 21, 2020
Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS DisordersSimone Bonazzi, Carleton P Goold, Audrey Gray, et al.Journal of Medicinal Chemistry|July 3, 2023
Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS SyndromesSimone Bonazzi, Audrey Gray, Noel M Thomsen, et al.Science (New York, N.Y.)|July 4, 2024
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin inductionPamela Y Ting, Sneha Borikar, John Ryan Kerrigan, et al.Cell Chemical Biology|March 2, 2023
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapySimone Bonazzi, Eva d'Hennezel, Rohan E J Beckwith, et al.Pageof 1