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The Biochemical Journal|October 16, 2004
Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAPDomagoj Vucic, Matthew C Franklin, Heidi J A Wallweber, et al.Bioorganic & Medicinal Chemistry Letters|March 2, 2010
Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteresFrederick Cohen, Michael F T Koehler, Philippe Bergeron, et al.Biochemistry|July 9, 2003
Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP)Matthew C Franklin, Saloumeh Kadkhodayan, Heidi Ackerly, et al.Journal of Medicinal Chemistry|February 21, 2009
Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffoldFrederick Cohen, Bruno Alicke, Linda O Elliott, et al.ACS Chemical Biology|June 5, 2009
Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonistsChudi Ndubaku, Eugene Varfolomeev, Lan Wang, et al.Cell|November 21, 2007
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosisEugene Varfolomeev, John W Blankenship, Sarah M Wayson, et al.The Journal of Biological Chemistry|January 6, 2005
A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivoAlan G Olivero, Charles Eigenbrot, Richard Goldsmith, et al.Journal of Medicinal Chemistry|March 15, 2012
Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)John A Flygare, Maureen Beresini, Nageshwar Budha, et al.Pageof 9