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Investigational New Drugs|July 1, 2015
P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclibMark C de Gooijer, Ping Zhang, Nishita Thota, et al.
Anti-Cancer Drugs|March 14, 2003
Metabolism of paclitaxel in miceHeleen A Bardelmeijer, Ingrid A M Oomen, Michel J X Hillebrand, et al.
Scientific Reports|July 19, 2018
Buparlisib is a brain penetrable pan-PI3K inhibitorMark C de Gooijer, Ping Zhang, Levi C M Buil, et al.
Fluids and Barriers of the CNS|August 5, 2024
ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brainAristeidis Lentzas, Mark C de Gooijer, Stefanie Zuidema, et al.
Mechanisms of Ageing and Development|February 18, 2026
Antiretroviral Raltegravir, a Selective Human Immunodeficiency Virus Type 1 Integrase Inhibitor, Shows Anti-Alzheimer's Potential against Amyloid-Beta1-42-Induced NeurodegenerationMehdi Alami, Hicham Berrougui, Kaoutar Boumezough, et al.
Cell Death and Differentiation|December 20, 2024
Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent stateFleur Jochems, Chrysiida Baltira, Julie A MacDonald, et al.
Cancer Chemotherapy and Pharmacology|May 3, 2005
Metabolism of docetaxel in miceHeleen A Bardelmeijer, Arjan B G H Roelofs, Michel J X Hillebrand, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|October 26, 2006
Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokineticsJurjen S Lagas, Maria L Vlaming, Olaf van Tellingen, et al.
Neoplasia (New York, N.Y.)|June 1, 2018
Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2Mark C de Gooijer, Nienke A de Vries, Tessa Buckle, et al.
Cell Reports. Medicine|February 1, 2021
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lostMark C de Gooijer, E Marleen Kemper, Levi C M Buil, et al.
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