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Acta Neuropathologica|April 24, 2009
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophyHenning Breyhan, Oliver Wirths, Kailai Duan, et al.
Journal of Alzheimer'S Disease : JAD|November 20, 2014
Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's diseaseMelanie Hüttenrauch, Sandra Baches, Janina Gerth, et al.
Acta Neuropathologica|March 26, 2013
Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer's diseaseSathish Kumar, Oliver Wirths, Sandra Theil, et al.
Neurobiology of Aging|April 3, 2010
Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI miceMarie-Caroline Cotel, Sadim Jawhar, Ditte Z Christensen, et al.
Acta Neuropathologica|June 24, 2009
Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse modelOliver Wirths, Henning Breyhan, Holger Cynis, et al.
Acta Neuropathologica|March 11, 2010
Accumulation of intraneuronal Abeta correlates with ApoE4 genotypeDitte Z Christensen, Thomas Schneider-Axmann, Paul J Lucassen, et al.
Journal of Alzheimer'S Disease : JAD|February 21, 2015
Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's DiseaseBernhard Clemens Richard, Anastasiia Kurdakova, Sandra Baches, et al.
Neurobiology of Aging|July 29, 2008
Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's diseaseOliver Wirths, Henning Breyhan, Andrea Marcello, et al.
The Journal of Biological Chemistry|December 15, 2010
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD miceSadim Jawhar, Oliver Wirths, Stephan Schilling, et al.
Journal of Alzheimer'S Disease : JAD|January 11, 2012
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregatesVivek Venkataramani, Oliver Wirths, Herbert Budka, et al.
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