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Molecular Psychiatry|August 18, 2018
Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulatorsSamantha E Yohn, Daniel J Foster, Dan P Covey, et al.
Bioorganic & Medicinal Chemistry Letters|September 21, 2011
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071Evan P Lebois, Gregory J Digby, Douglas J Sheffler, et al.
ERJ Open Research|January 15, 2025
Repeat expansions in RFC1 gene in refractory chronic coughBarnaby Hirons, Peter S P Cho, Katie Rhatigan, et al.
Lung|August 8, 2025
Unnerving Cough in CANVAS: Cough Hypersensitivity Despite Airway Nerve DepletionBarnaby Hirons, Katherine Rhatigan, William McNulty, et al.
ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide CoreKatrina A Bollinger, Andrew S Felts, Christopher J Brassard, et al.
Chemmedchem|April 3, 2014
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probePatrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Molecular Pharmacology|October 25, 2011
Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system functionMeredith J Noetzel, Jerri M Rook, Paige N Vinson, et al.
ACS Chemical Neuroscience|August 8, 2018
Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M1 Positive Allosteric ModulatorsJulie L Engers, Aaron M Bender, Jacob J Kalbfleisch, et al.
ACS Chemical Neuroscience|September 13, 2016
Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256Michael D Grannan, Catharine A Mielnik, Sean P Moran, et al.
Bioorganic & Medicinal Chemistry Letters|October 28, 2021
Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes - Part 2Madeline F Long, Rory A Capstick, Paul K Spearing, et al.
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