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Bioorganic & Medicinal Chemistry Letters|April 18, 2012
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptorBruce J Melancon, Rocco D Gogliotti, James C Tarr, et al.
ACS Chemical Neuroscience|June 23, 2026
Discovery of VU6066098: A Selective and CNS-Penetrant mGlu2 NAM with Robust Antidepressant-, Antipsychotic-, and Procognitive-like Activity in RodentsJeremy S Coleman, Rory A Capstick, Sichen Chang, et al.
ACS Chemical Neuroscience|November 23, 2012
Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169James C Tarr, Mark L Turlington, Paul R Reid, et al.
ACS Chemical Neuroscience|September 24, 2024
Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)Julie L Engers, Logan A Baker, Sichen Chang, et al.
ACS Chemical Neuroscience|April 28, 2018
A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic ToxicityJerri M Rook, Jeanette L Bertron, Hyekyung P Cho, et al.
Bioorganic & Medicinal Chemistry Letters|May 20, 2017
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amidesJames C Tarr, Michael R Wood, Meredith J Noetzel, et al.
ACS Chemical Neuroscience|December 22, 2016
Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMsJerri M Rook, Masahito Abe, Hyekyung P Cho, et al.
ACS Medicinal Chemistry Letters|July 16, 2025
Discovery of a Novel sp3‑Rich M1 Positive Allosteric Modulators (PAMs) Chemotype via Scaffold HoppingJoseph D Bungard, Paul Spearing, Yu Nishio, et al.
Biological Psychiatry|November 13, 2012
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activityJerri M Rook, Meredith J Noetzel, Wendy A Pouliot, et al.
ACS Chemical Neuroscience|August 28, 2024
Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup CandidateJulie L Engers, Katrina A Bollinger, Rory A Capstick, et al.
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