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Bioorganic & Medicinal Chemistry Letters|November 2, 2017
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amidesJames C Tarr, Michael R Wood, Meredith J Noetzel, et al.
ACS Chemical Neuroscience|March 25, 2025
Application of Deuterium in an M1 Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422Julie L Engers, Jinming Li, Changho Han, et al.
Molecular Cancer Therapeutics|August 20, 2021
SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging AgentsJessica Gartrell, Marcia Mellado-Largarde, Michael R Clay, et al.
ACS Chemical Neuroscience|February 5, 2025
Further Optimization of the mGlu1 PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
Bioorganic & Medicinal Chemistry Letters|December 13, 2016
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogsMichael R Wood, Meredith J Noetzel, Michael S Poslusney, et al.
Bioorganic & Medicinal Chemistry Letters|April 27, 2017
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacologyBruce J Melancon, Michael R Wood, Meredith J Noetzel, et al.
ACS Chemical Neuroscience|April 22, 2018
Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide ScaffoldAaron M Bender, Hyekyung P Cho, Kellie D Nance, et al.
ACS Chemical Neuroscience|July 7, 2026
Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory NeuronsTomayo I Berida, Cayden J Dodd, Joshua C Wilkinson, et al.
ACS Chemical Neuroscience|November 26, 2025
Discovery of VU6052254: A Novel, Potent M1 Positive Allosteric ModulatorJulie L Engers, Joseph D Bungard, Christopher C Presley, et al.
Journal of Medicinal Chemistry|August 6, 2024
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine ReceptorJinming Li, Douglas L Orsi, Julie L Engers, et al.
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