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Showing results (241-250 of 299) with videos related to

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Bioorganic & Medicinal Chemistry Letters|June 22, 2017
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonistsAaron M Bender, Rebecca L Weiner, Vincent B Luscombe, et al.
Bioorganic & Medicinal Chemistry Letters|March 26, 2023
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTSCayden J Dodd, Keagan S Chronister, Upendra Rathnayake, et al.
Bioorganic & Medicinal Chemistry Letters|September 4, 2017
Discovery of a novel, CNS penetrant M<sub>4</sub> PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile coreBlake R Bewley, Paul K Spearing, Rebecca L Weiner, et al.
Bioorganic & Medicinal Chemistry Letters|October 18, 2017
Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotype via scaffold hoppingMadeline F Long, Julie L Engers, Sichen Chang, et al.
Journal of Medicinal Chemistry|August 23, 2014
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|December 4, 2012
Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonismDouglas J Sheffler, Christian Sevel, Uyen Le, et al.
Bioorganic & Medicinal Chemistry Letters|January 4, 2011
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probePaul R Reid, Thomas M Bridges, Douglas J Sheffler, et al.
ACS Medicinal Chemistry Letters|September 28, 2018
VU6007477, a Novel M<sub>1</sub> PAM Based on a Pyrrolo[2,3-<i>b</i>]pyridine Carboxamide Core Devoid of Cholinergic Adverse EventsJulie L Engers, Elizabeth S Childress, Madeline F Long, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|March 28, 2018
M<sub>1</sub>-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognitionSean P Moran, Jonathan W Dickerson, Hyekyung P Cho, et al.
ACS Chemical Biology|August 20, 2014
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsHyekyung P Cho, Pedro M Garcia-Barrantes, John T Brogan, et al.
Pageof 30

Showing results (241-250 of 299) with videos related to

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Pageof 30
Bioorganic & Medicinal Chemistry Letters|June 22, 2017
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonistsAaron M Bender, Rebecca L Weiner, Vincent B Luscombe, et al.
Bioorganic & Medicinal Chemistry Letters|March 26, 2023
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTSCayden J Dodd, Keagan S Chronister, Upendra Rathnayake, et al.
Bioorganic & Medicinal Chemistry Letters|September 4, 2017
Discovery of a novel, CNS penetrant M<sub>4</sub> PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile coreBlake R Bewley, Paul K Spearing, Rebecca L Weiner, et al.
Bioorganic & Medicinal Chemistry Letters|October 18, 2017
Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotype via scaffold hoppingMadeline F Long, Julie L Engers, Sichen Chang, et al.
Journal of Medicinal Chemistry|August 23, 2014
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|December 4, 2012
Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonismDouglas J Sheffler, Christian Sevel, Uyen Le, et al.
Bioorganic & Medicinal Chemistry Letters|January 4, 2011
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probePaul R Reid, Thomas M Bridges, Douglas J Sheffler, et al.
ACS Medicinal Chemistry Letters|September 28, 2018
VU6007477, a Novel M<sub>1</sub> PAM Based on a Pyrrolo[2,3-<i>b</i>]pyridine Carboxamide Core Devoid of Cholinergic Adverse EventsJulie L Engers, Elizabeth S Childress, Madeline F Long, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|March 28, 2018
M<sub>1</sub>-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognitionSean P Moran, Jonathan W Dickerson, Hyekyung P Cho, et al.
ACS Chemical Biology|August 20, 2014
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsHyekyung P Cho, Pedro M Garcia-Barrantes, John T Brogan, et al.
Pageof 30