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Showing results (251-260 of 299) with videos related to

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Journal of Medicinal Chemistry|April 17, 2014
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependenceRaveendra-Panickar Dhanya, Douglas J Sheffler, Russell Dahl, et al.
Journal of Medicinal Chemistry|October 30, 2013
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Journal of Medicinal Chemistry|October 24, 2018
Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu<sub>2</sub>) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- a]pyrimidine-5-carboxamide and Thieno[3,2- b]pyridine-5-carboxamide CoresElizabeth S Childress, Joshua M Wieting, Andrew S Felts, et al.
Bioorganic & Medicinal Chemistry Letters|May 15, 2018
The discovery of VU0486846: steep SAR from a series of M<sub>1</sub> PAMs based on a novel benzomorpholine coreJeanette L Bertron, Hyekyung P Cho, Pedro M Garcia-Barrantes, et al.
Molecular Psychiatry|August 18, 2018
Activation of the mGlu<sub>1</sub> metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M<sub>4</sub> muscarinic receptor allosteric modulatorsSamantha E Yohn, Daniel J Foster, Dan P Covey, et al.
Bioorganic & Medicinal Chemistry Letters|September 21, 2011
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071Evan P Lebois, Gregory J Digby, Douglas J Sheffler, et al.
ERJ Open Research|January 15, 2025
Repeat expansions in <i>RFC1</i> gene in refractory chronic coughBarnaby Hirons, Peter S P Cho, Katie Rhatigan, et al.
Lung|August 8, 2025
Unnerving Cough in CANVAS: Cough Hypersensitivity Despite Airway Nerve DepletionBarnaby Hirons, Katherine Rhatigan, William McNulty, et al.
Chemmedchem|April 3, 2014
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probePatrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of mGlu<sub>2</sub> NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide CoreKatrina A Bollinger, Andrew S Felts, Christopher J Brassard, et al.
Pageof 30

Showing results (251-260 of 299) with videos related to

Sort By:
Pageof 30
Journal of Medicinal Chemistry|April 17, 2014
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependenceRaveendra-Panickar Dhanya, Douglas J Sheffler, Russell Dahl, et al.
Journal of Medicinal Chemistry|October 30, 2013
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Journal of Medicinal Chemistry|October 24, 2018
Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu<sub>2</sub>) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- a]pyrimidine-5-carboxamide and Thieno[3,2- b]pyridine-5-carboxamide CoresElizabeth S Childress, Joshua M Wieting, Andrew S Felts, et al.
Bioorganic & Medicinal Chemistry Letters|May 15, 2018
The discovery of VU0486846: steep SAR from a series of M<sub>1</sub> PAMs based on a novel benzomorpholine coreJeanette L Bertron, Hyekyung P Cho, Pedro M Garcia-Barrantes, et al.
Molecular Psychiatry|August 18, 2018
Activation of the mGlu<sub>1</sub> metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M<sub>4</sub> muscarinic receptor allosteric modulatorsSamantha E Yohn, Daniel J Foster, Dan P Covey, et al.
Bioorganic & Medicinal Chemistry Letters|September 21, 2011
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071Evan P Lebois, Gregory J Digby, Douglas J Sheffler, et al.
ERJ Open Research|January 15, 2025
Repeat expansions in <i>RFC1</i> gene in refractory chronic coughBarnaby Hirons, Peter S P Cho, Katie Rhatigan, et al.
Lung|August 8, 2025
Unnerving Cough in CANVAS: Cough Hypersensitivity Despite Airway Nerve DepletionBarnaby Hirons, Katherine Rhatigan, William McNulty, et al.
Chemmedchem|April 3, 2014
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probePatrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of mGlu<sub>2</sub> NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide CoreKatrina A Bollinger, Andrew S Felts, Christopher J Brassard, et al.
Pageof 30