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Bioorganic & Medicinal Chemistry Letters
|
April 27, 2017
Optimization of M<sub>4</sub> positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology
Bruce J Melancon, Michael R Wood, Meredith J Noetzel, et al.
ACS Chemical Neuroscience
|
April 22, 2018
Discovery and Optimization of Potent and CNS Penetrant M<sub>5</sub>-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold
Aaron M Bender, Hyekyung P Cho, Kellie D Nance, et al.
ACS Chemical Neuroscience
|
July 7, 2026
Discovery of VU6077564: A Selective M<sub>1</sub> Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons
Tomayo I Berida, Cayden J Dodd, Joshua C Wilkinson, et al.
ACS Chemical Neuroscience
|
November 26, 2025
Discovery of VU6052254: A Novel, Potent M<sub>1</sub> Positive Allosteric Modulator
Julie L Engers, Joseph D Bungard, Christopher C Presley, et al.
Journal of Medicinal Chemistry
|
August 6, 2024
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M<sub>5</sub> Muscarinic Acetylcholine Receptor
Jinming Li, Douglas L Orsi, Julie L Engers, et al.
ACS Chemical Neuroscience
|
January 26, 2026
Discovery of 7-(Pyridin-3-yl)thieno[3,2-<i>b</i>]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Scott H Henderson, Anna E Ringuette, David L Whomble, et al.
ACS Pharmacology & Translational Science
|
August 23, 2021
Discovery of the First Selective M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonists with <i>in Vivo</i> Antiparkinsonian and Antidystonic Efficacy
Mark S Moehle, Aaron M Bender, Jonathan W Dickerson, et al.
ACS Medicinal Chemistry Letters
|
December 18, 2024
Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, et al.
Journal of Medicinal Chemistry
|
December 12, 2024
Discovery of VU6024578/BI02982816: An mGlu<sub>1</sub> Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
Neuro-Oncology Pediatrics
|
March 27, 2026
Targeting the p53 pathway to treat atypical teratoid rhabdoid tumors
Alaa Refaat, Hyekyung P Cho, Justin S Williams, et al.
Page
of 30
Search research articles
Search
Showing results (281-290 of 299) with videos related to
Sort By:
Page
of 30
Bioorganic & Medicinal Chemistry Letters
|
April 27, 2017
Optimization of M<sub>4</sub> positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology
Bruce J Melancon, Michael R Wood, Meredith J Noetzel, et al.
ACS Chemical Neuroscience
|
April 22, 2018
Discovery and Optimization of Potent and CNS Penetrant M<sub>5</sub>-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold
Aaron M Bender, Hyekyung P Cho, Kellie D Nance, et al.
ACS Chemical Neuroscience
|
July 7, 2026
Discovery of VU6077564: A Selective M<sub>1</sub> Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons
Tomayo I Berida, Cayden J Dodd, Joshua C Wilkinson, et al.
ACS Chemical Neuroscience
|
November 26, 2025
Discovery of VU6052254: A Novel, Potent M<sub>1</sub> Positive Allosteric Modulator
Julie L Engers, Joseph D Bungard, Christopher C Presley, et al.
Journal of Medicinal Chemistry
|
August 6, 2024
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M<sub>5</sub> Muscarinic Acetylcholine Receptor
Jinming Li, Douglas L Orsi, Julie L Engers, et al.
ACS Chemical Neuroscience
|
January 26, 2026
Discovery of 7-(Pyridin-3-yl)thieno[3,2-<i>b</i>]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Scott H Henderson, Anna E Ringuette, David L Whomble, et al.
ACS Pharmacology & Translational Science
|
August 23, 2021
Discovery of the First Selective M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonists with <i>in Vivo</i> Antiparkinsonian and Antidystonic Efficacy
Mark S Moehle, Aaron M Bender, Jonathan W Dickerson, et al.
ACS Medicinal Chemistry Letters
|
December 18, 2024
Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, et al.
Journal of Medicinal Chemistry
|
December 12, 2024
Discovery of VU6024578/BI02982816: An mGlu<sub>1</sub> Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
Neuro-Oncology Pediatrics
|
March 27, 2026
Targeting the p53 pathway to treat atypical teratoid rhabdoid tumors
Alaa Refaat, Hyekyung P Cho, Justin S Williams, et al.
Page
of 30