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ACS Bio & Med Chem Au|April 27, 2023
Discovery of "Molecular Switches" within a Series of mGlu5 Allosteric Ligands Driven by a "Magic Methyl" Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM ChemotypeLisa Barbaro, Alice L Rodriguez, Ashlyn N Blevins, et al.Bioorganic & Medicinal Chemistry Letters|March 27, 2019
Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278Carson W Reed, Jordan P Washecheck, Marc C Quitlag, et al.Journal of Medicinal Chemistry|December 16, 2010
Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in ratsRaveendra-Panickar Dhanya, Shyama Sidique, Douglas J Sheffler, et al.Journal of Medicinal Chemistry|May 15, 2009
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatinsThomas M Bridges, Joy E Marlo, Colleen M Niswender, et al.Science (New York, N.Y.)|March 8, 2014
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulatorHuixian Wu, Chong Wang, Karen J Gregory, et al.Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society|October 14, 2025
Analysis of the impact of female sex and muscle mass on serum creatinine and waitlist priority for liver transplantationShivangi Gupta, Angus W Jeffrey, Zhengyi Wang, et al.Transplantation Proceedings|September 16, 2020
Trends and Outcomes in Simultaneous Liver and Kidney Transplantation in Australia and New ZealandDouglas Drak, Nishanta Tangirala, Michael Fink, et al.Journal of Medicinal Chemistry|October 2, 2015
Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in SchizophrenicsPedro M Garcia-Barrantes, Hyekyung P Cho, Colleen M Niswender, et al.ACS Chemical Neuroscience|September 14, 2010
Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulationAlbert A Davis, Craig J Heilman, Ashley E Brady, et al.Bioorganic & Medicinal Chemistry Letters|April 30, 2018
Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5Andrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.Pageof 113