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Molecular Pharmacology|August 16, 2003
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5Julie A O'Brien, Wei Lemaire, Tsing-Bau Chen, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|March 20, 2009
mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learningJennifer E Ayala, Yelin Chen, Jessica L Banko, et al.
Bioorganic & Medicinal Chemistry Letters|September 23, 2008
Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moietiesThomas M Bridges, Ashley E Brady, J Phillip Kennedy, et al.
World Journal of Hepatology|October 1, 2024
Predictors of survival in autoimmune liver disease overlap syndromesDujinthan Jayabalan, Yi Huang, Luis Calzadilla-Bertot, et al.
Bioorganic & Medicinal Chemistry Letters|December 25, 2018
Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligandsMichael S Poslusney, James M Salovich, Michael R Wood, et al.
ACS Chemical Neuroscience|May 21, 2013
Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addictionRussell J Amato, Andrew S Felts, Alice L Rodriguez, et al.
Bioorganic & Medicinal Chemistry Letters|November 18, 2018
Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5Andrew S Felts, Katrina A Bollinger, Christopher J Brassard, et al.
Bioorganic & Medicinal Chemistry Letters|June 4, 2013
N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in ratsKimberly M Lovell, Andrew S Felts, Alice L Rodriguez, et al.
Bioorganic & Medicinal Chemistry Letters|September 16, 2022
Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonistsRory A Capstick, David Whomble, Douglas L Orsi, et al.
Bioorganic & Medicinal Chemistry Letters|May 14, 2016
Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetrationJoseph D Panarese, Hykeyung P Cho, Jeffrey J Adams, et al.
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