Showing results (951-960 of 1,124) with videos related to
Sort By:
Pageof 113
Bioorganic & Medicinal Chemistry Letters|May 29, 2016
Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)Rocco D Gogliotti, Anna L Blobaum, Ryan M Morrison, et al.Bioorganic & Medicinal Chemistry Letters|June 22, 2017
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonistsAaron M Bender, Rebecca L Weiner, Vincent B Luscombe, et al.Bioorganic & Medicinal Chemistry Letters|March 19, 2016
N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodentsAndrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.Bioorganic & Medicinal Chemistry Letters|April 9, 2013
Discovery of ML326: The first sub-micromolar, selective M5 PAMPatrick R Gentry, Thomas M Bridges, Atin Lamsal, et al.Bioorganic & Medicinal Chemistry Letters|January 8, 2008
Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonistsL Michelle Lewis, Douglas Sheffler, Richard Williams, et al.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|September 23, 2014
Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profilesJerri M Rook, Mohammed N Tantawy, Mohammad S Ansari, et al.Bioorganic & Medicinal Chemistry Letters|September 4, 2017
Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile coreBlake R Bewley, Paul K Spearing, Rebecca L Weiner, et al.Cancers|June 10, 2022
Expansion of Liver Transplantation Criteria for Hepatocellular Carcinoma from Milan to UCSF in Australia and New Zealand and Justification for Metroticket 2.0Savio G Barreto, Simone I Strasser, Geoffrey W McCaughan, et al.Bioorganic & Medicinal Chemistry Letters|October 18, 2017
Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hoppingMadeline F Long, Julie L Engers, Sichen Chang, et al.Journal of Biomolecular Screening|April 17, 2015
Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)Emery Smith, Peter Chase, Colleen M Niswender, et al.Pageof 113