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British Journal of Pharmacology|May 24, 2000
Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonistJ J Hagan, G W Price, P Jeffrey, et al.Bioorganic & Medicinal Chemistry Letters|December 1, 2019
Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotypeKayla J Temple, Julie L Engers, Madeline F Long, et al.Neuron|November 22, 2015
M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced DyskinesiaWeixing Shen, Joshua L Plotkin, Veronica Francardo, et al.Human Molecular Genetics|March 4, 2016
mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndromeRocco G Gogliotti, Rebecca K Senter, Jerri M Rook, et al.Neuropharmacology|July 22, 2017
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154Robert W Gould, Michael D Grannan, Barak W Gunter, et al.ACS Medicinal Chemistry Letters|September 28, 2018
VU6007477, a Novel M1 PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse EventsJulie L Engers, Elizabeth S Childress, Madeline F Long, et al.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|March 28, 2018
M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognitionSean P Moran, Jonathan W Dickerson, Hyekyung P Cho, et al.Hepatology (Baltimore, Md.)|September 26, 2020
ABIDE: An Accurate Predictive Model of Liver Decompensation in Patients With Nonalcoholic Fatty Liver-Related CirrhosisLuis Calzadilla-Bertot, Eduardo Vilar-Gomez, Vincent Wai-Sun Wong, et al.Journal of Medicinal Chemistry|January 5, 2019
Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu7 Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1 H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962)Carson W Reed, Samantha E Yohn, Jordan P Washecheck, et al.ACS Chemical Biology|August 20, 2014
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsHyekyung P Cho, Pedro M Garcia-Barrantes, John T Brogan, et al.Pageof 113