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Showing results (481-490 of 651) with videos related to

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ACS Chemical Neuroscience|May 21, 2013
Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addictionRussell J Amato, Andrew S Felts, Alice L Rodriguez, et al.
Bioorganic & Medicinal Chemistry Letters|November 18, 2018
Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5Andrew S Felts, Katrina A Bollinger, Christopher J Brassard, et al.
Bioorganic & Medicinal Chemistry Letters|June 4, 2013
N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in ratsKimberly M Lovell, Andrew S Felts, Alice L Rodriguez, et al.
Bioorganic & Medicinal Chemistry Letters|September 16, 2022
Discovery of a potent M<sub>5</sub> antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonistsRory A Capstick, David Whomble, Douglas L Orsi, et al.
Bioorganic & Medicinal Chemistry Letters|May 14, 2016
Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetrationJoseph D Panarese, Hykeyung P Cho, Jeffrey J Adams, et al.
Bioorganic & Medicinal Chemistry Letters|May 29, 2016
Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)Rocco D Gogliotti, Anna L Blobaum, Ryan M Morrison, et al.
Bioorganic & Medicinal Chemistry Letters|June 22, 2017
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonistsAaron M Bender, Rebecca L Weiner, Vincent B Luscombe, et al.
Bioorganic & Medicinal Chemistry Letters|March 19, 2016
N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodentsAndrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
Bioorganic & Medicinal Chemistry Letters|April 9, 2013
Discovery of ML326: The first sub-micromolar, selective M5 PAMPatrick R Gentry, Thomas M Bridges, Atin Lamsal, et al.
Bioorganic & Medicinal Chemistry Letters|January 8, 2008
Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonistsL Michelle Lewis, Douglas Sheffler, Richard Williams, et al.
Pageof 66

Showing results (481-490 of 651) with videos related to

Sort By:
Pageof 66
ACS Chemical Neuroscience|May 21, 2013
Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addictionRussell J Amato, Andrew S Felts, Alice L Rodriguez, et al.
Bioorganic & Medicinal Chemistry Letters|November 18, 2018
Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5Andrew S Felts, Katrina A Bollinger, Christopher J Brassard, et al.
Bioorganic & Medicinal Chemistry Letters|June 4, 2013
N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in ratsKimberly M Lovell, Andrew S Felts, Alice L Rodriguez, et al.
Bioorganic & Medicinal Chemistry Letters|September 16, 2022
Discovery of a potent M<sub>5</sub> antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonistsRory A Capstick, David Whomble, Douglas L Orsi, et al.
Bioorganic & Medicinal Chemistry Letters|May 14, 2016
Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetrationJoseph D Panarese, Hykeyung P Cho, Jeffrey J Adams, et al.
Bioorganic & Medicinal Chemistry Letters|May 29, 2016
Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)Rocco D Gogliotti, Anna L Blobaum, Ryan M Morrison, et al.
Bioorganic & Medicinal Chemistry Letters|June 22, 2017
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonistsAaron M Bender, Rebecca L Weiner, Vincent B Luscombe, et al.
Bioorganic & Medicinal Chemistry Letters|March 19, 2016
N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodentsAndrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
Bioorganic & Medicinal Chemistry Letters|April 9, 2013
Discovery of ML326: The first sub-micromolar, selective M5 PAMPatrick R Gentry, Thomas M Bridges, Atin Lamsal, et al.
Bioorganic & Medicinal Chemistry Letters|January 8, 2008
Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonistsL Michelle Lewis, Douglas Sheffler, Richard Williams, et al.
Pageof 66