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Showing results (541-550 of 651) with videos related to

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ACS Chemical Neuroscience|October 1, 2011
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous systemEvan P Lebois, Thomas M Bridges, L Michelle Lewis, et al.
Chemmedchem|April 3, 2014
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probePatrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|May 2, 2016
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacyRocco D Gogliotti, Darren W Engers, Pedro M Garcia-Barrantes, et al.
Bioorganic & Medicinal Chemistry Letters|June 29, 2012
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptorJames M Salovich, Paige N Vinson, Douglas J Sheffler, et al.
Bioorganic & Medicinal Chemistry Letters|September 30, 2017
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5Andrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
Science Translational Medicine|August 18, 2017
mGlu<sub>7</sub> potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndromeRocco G Gogliotti, Rebecca K Senter, Nicole M Fisher, et al.
Bioorganic & Medicinal Chemistry Letters|October 1, 2013
Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyAndrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of mGlu<sub>2</sub> NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide CoreKatrina A Bollinger, Andrew S Felts, Christopher J Brassard, et al.
ACS Chemical Neuroscience|February 18, 2014
Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric siteKaren J Gregory, Elizabeth D Nguyen, Chrysa Malosh, et al.
Hepatology (Baltimore, Md.)|March 6, 2009
Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapySilvana Gaudieri, Andri Rauch, Katja Pfafferott, et al.
Pageof 66

Showing results (541-550 of 651) with videos related to

Sort By:
Pageof 66
ACS Chemical Neuroscience|October 1, 2011
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous systemEvan P Lebois, Thomas M Bridges, L Michelle Lewis, et al.
Chemmedchem|April 3, 2014
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probePatrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|May 2, 2016
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacyRocco D Gogliotti, Darren W Engers, Pedro M Garcia-Barrantes, et al.
Bioorganic & Medicinal Chemistry Letters|June 29, 2012
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptorJames M Salovich, Paige N Vinson, Douglas J Sheffler, et al.
Bioorganic & Medicinal Chemistry Letters|September 30, 2017
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5Andrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
Science Translational Medicine|August 18, 2017
mGlu<sub>7</sub> potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndromeRocco G Gogliotti, Rebecca K Senter, Nicole M Fisher, et al.
Bioorganic & Medicinal Chemistry Letters|October 1, 2013
Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyAndrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of mGlu<sub>2</sub> NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide CoreKatrina A Bollinger, Andrew S Felts, Christopher J Brassard, et al.
ACS Chemical Neuroscience|February 18, 2014
Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric siteKaren J Gregory, Elizabeth D Nguyen, Chrysa Malosh, et al.
Hepatology (Baltimore, Md.)|March 6, 2009
Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapySilvana Gaudieri, Andri Rauch, Katja Pfafferott, et al.
Pageof 66