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Showing results (571-580 of 651) with videos related to

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Clinical Transplantation|December 13, 2023
Impact of Share 35 liver transplantation allocation in Australia and New ZealandMichael A Fink, Paul J Gow, Geoffrey W McCaughan, et al.
The Journal of Pharmacology and Experimental Therapeutics|October 28, 2015
VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo EfficacyHilary Highfield Nickols, Joannes P Yuh, Karen J Gregory, et al.
The Journal of Pharmacology and Experimental Therapeutics|November 18, 2011
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's diseaseCarrie K Jones, Michael Bubser, Analisa D Thompson, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 5, 2013
Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactionsAnna L Blobaum, Thomas M Bridges, Frank W Byers, et al.
Current Topics in Medicinal Chemistry|October 8, 2009
Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probeC David Weaver, Douglas J Sheffler, L Michelle Lewis, et al.
Neuropharmacology|December 1, 2015
State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effectsRobert W Gould, Michael T Nedelcovych, Xuewen Gong, et al.
Bioorganic & Medicinal Chemistry Letters|April 18, 2012
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptorBruce J Melancon, Rocco D Gogliotti, James C Tarr, et al.
ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of <i>N</i>-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu<sub>3</sub> NAMsJulie L Engers, Katrina A Bollinger, Rebecca L Weiner, et al.
Bioorganic & Medicinal Chemistry Letters|November 27, 2012
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophreniaUyen Le, Bruce J Melancon, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|June 26, 2014
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiencyMark Turlington, Meredith J Noetzel, Thomas M Bridges, et al.
Pageof 66

Showing results (571-580 of 651) with videos related to

Sort By:
Pageof 66
Clinical Transplantation|December 13, 2023
Impact of Share 35 liver transplantation allocation in Australia and New ZealandMichael A Fink, Paul J Gow, Geoffrey W McCaughan, et al.
The Journal of Pharmacology and Experimental Therapeutics|October 28, 2015
VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo EfficacyHilary Highfield Nickols, Joannes P Yuh, Karen J Gregory, et al.
The Journal of Pharmacology and Experimental Therapeutics|November 18, 2011
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's diseaseCarrie K Jones, Michael Bubser, Analisa D Thompson, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 5, 2013
Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactionsAnna L Blobaum, Thomas M Bridges, Frank W Byers, et al.
Current Topics in Medicinal Chemistry|October 8, 2009
Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probeC David Weaver, Douglas J Sheffler, L Michelle Lewis, et al.
Neuropharmacology|December 1, 2015
State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effectsRobert W Gould, Michael T Nedelcovych, Xuewen Gong, et al.
Bioorganic & Medicinal Chemistry Letters|April 18, 2012
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptorBruce J Melancon, Rocco D Gogliotti, James C Tarr, et al.
ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of <i>N</i>-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu<sub>3</sub> NAMsJulie L Engers, Katrina A Bollinger, Rebecca L Weiner, et al.
Bioorganic & Medicinal Chemistry Letters|November 27, 2012
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophreniaUyen Le, Bruce J Melancon, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|June 26, 2014
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiencyMark Turlington, Meredith J Noetzel, Thomas M Bridges, et al.
Pageof 66