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Journal of Medicinal Chemistry
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August 6, 2024
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M<sub>5</sub> Muscarinic Acetylcholine Receptor
Jinming Li, Douglas L Orsi, Julie L Engers, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 18, 2015
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators
Chrysa Malosh, Mark Turlington, Thomas M Bridges, et al.
ACS Chemical Neuroscience
|
January 26, 2026
Discovery of 7-(Pyridin-3-yl)thieno[3,2-<i>b</i>]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Scott H Henderson, Anna E Ringuette, David L Whomble, et al.
ACS Pharmacology & Translational Science
|
August 23, 2021
Discovery of the First Selective M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonists with <i>in Vivo</i> Antiparkinsonian and Antidystonic Efficacy
Mark S Moehle, Aaron M Bender, Jonathan W Dickerson, et al.
ACS Medicinal Chemistry Letters
|
February 16, 2017
Discovery of VU0467485/AZ13713945: An M<sub>4</sub> PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia
Michael R Wood, Meredith J Noetzel, Bruce J Melancon, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
June 20, 2012
The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5
Ryan D Morrison, Anna L Blobaum, Frank W Byers, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 23, 2019
VU6005806/AZN-00016130, an advanced M<sub>4</sub> positive allosteric modulator (PAM) profiled as a potential preclinical development candidate
Darren W Engers, Bruce J Melancon, Allison R Gregro, et al.
ACS Medicinal Chemistry Letters
|
December 18, 2024
Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, et al.
Journal of Medicinal Chemistry
|
December 12, 2024
Discovery of VU6024578/BI02982816: An mGlu<sub>1</sub> Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
ACS Chemical Neuroscience
|
September 17, 2014
Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7
Nidhi Jalan-Sakrikar, Julie R Field, Rebecca Klar, et al.
Page
of 66
Search research articles
Search
Showing results (621-630 of 651) with videos related to
Sort By:
Page
of 66
Journal of Medicinal Chemistry
|
August 6, 2024
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M<sub>5</sub> Muscarinic Acetylcholine Receptor
Jinming Li, Douglas L Orsi, Julie L Engers, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 18, 2015
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators
Chrysa Malosh, Mark Turlington, Thomas M Bridges, et al.
ACS Chemical Neuroscience
|
January 26, 2026
Discovery of 7-(Pyridin-3-yl)thieno[3,2-<i>b</i>]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Scott H Henderson, Anna E Ringuette, David L Whomble, et al.
ACS Pharmacology & Translational Science
|
August 23, 2021
Discovery of the First Selective M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonists with <i>in Vivo</i> Antiparkinsonian and Antidystonic Efficacy
Mark S Moehle, Aaron M Bender, Jonathan W Dickerson, et al.
ACS Medicinal Chemistry Letters
|
February 16, 2017
Discovery of VU0467485/AZ13713945: An M<sub>4</sub> PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia
Michael R Wood, Meredith J Noetzel, Bruce J Melancon, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
June 20, 2012
The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5
Ryan D Morrison, Anna L Blobaum, Frank W Byers, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 23, 2019
VU6005806/AZN-00016130, an advanced M<sub>4</sub> positive allosteric modulator (PAM) profiled as a potential preclinical development candidate
Darren W Engers, Bruce J Melancon, Allison R Gregro, et al.
ACS Medicinal Chemistry Letters
|
December 18, 2024
Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, et al.
Journal of Medicinal Chemistry
|
December 12, 2024
Discovery of VU6024578/BI02982816: An mGlu<sub>1</sub> Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
ACS Chemical Neuroscience
|
September 17, 2014
Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7
Nidhi Jalan-Sakrikar, Julie R Field, Rebecca Klar, et al.
Page
of 66