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P Michael Conn

Showing results (91-100 of 101) with videos related to

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Molecular and Cellular Endocrinology|August 2, 2003
Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor functionGrégoy Y Bédécarrats, Katja D Linher, Jo Ann Janovick, et al.
Molecular and Cellular Endocrinology|February 1, 2011
Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadismGuadalupe Maya-Núñez, Jo Ann Janovick, Arturo Aguilar-Rojas, et al.
Assay and Drug Development Technologies|February 25, 2015
Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screeningFranck Madoux, Jo Ann Janovick, David Smithson, et al.
Pharmacological Research|December 31, 2013
Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screensP Michael Conn, David C Smithson, Peter S Hodder, et al.
Molecular Cell|April 2, 2014
Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHRScott A Houck, Hong Yu Ren, Victoria J Madden, et al.
Plos One|July 15, 2010
The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membraneMichelle Re, Macarena Pampillo, Martin Savard, et al.
Molecular Endocrinology (Baltimore, Md.)|December 31, 2004
A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutationAndrew J Pask, Haruhiko Kanasaki, Ursula B Kaiser, et al.
Molecular and Cellular Endocrinology|June 9, 2007
Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitroJo Ann Janovick, Shaun P Brothers, Anda Cornea, et al.
The Journal of Clinical Endocrinology and Metabolism|July 9, 2004
GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormoneAstrid U Meysing, Haruhiko Kanasaki, Gregoy Y Bedecarrats, et al.
Molecular Endocrinology (Baltimore, Md.)|August 25, 2012
Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failureM David Stewart, Jian Ming Deng, C Allison Stewart, et al.
Pageof 11

Showing results (91-100 of 101) with videos related to

Sort By:
Pageof 11
Molecular and Cellular Endocrinology|August 2, 2003
Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor functionGrégoy Y Bédécarrats, Katja D Linher, Jo Ann Janovick, et al.
Molecular and Cellular Endocrinology|February 1, 2011
Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadismGuadalupe Maya-Núñez, Jo Ann Janovick, Arturo Aguilar-Rojas, et al.
Assay and Drug Development Technologies|February 25, 2015
Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screeningFranck Madoux, Jo Ann Janovick, David Smithson, et al.
Pharmacological Research|December 31, 2013
Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screensP Michael Conn, David C Smithson, Peter S Hodder, et al.
Molecular Cell|April 2, 2014
Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHRScott A Houck, Hong Yu Ren, Victoria J Madden, et al.
Plos One|July 15, 2010
The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membraneMichelle Re, Macarena Pampillo, Martin Savard, et al.
Molecular Endocrinology (Baltimore, Md.)|December 31, 2004
A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutationAndrew J Pask, Haruhiko Kanasaki, Ursula B Kaiser, et al.
Molecular and Cellular Endocrinology|June 9, 2007
Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitroJo Ann Janovick, Shaun P Brothers, Anda Cornea, et al.
The Journal of Clinical Endocrinology and Metabolism|July 9, 2004
GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormoneAstrid U Meysing, Haruhiko Kanasaki, Gregoy Y Bedecarrats, et al.
Molecular Endocrinology (Baltimore, Md.)|August 25, 2012
Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failureM David Stewart, Jian Ming Deng, C Allison Stewart, et al.
Pageof 11