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Drug Metabolism and Disposition: the Biological Fate of Chemicals|March 21, 2009
Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selectionSantosh Kumar, Huan Qiu, Numan Oezguen, et al.
Archives of Biochemistry and Biophysics|March 6, 2004
Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helixEmily E Scott, Hong Liu, You Qun He, et al.
Biochemistry|April 29, 2009
Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioningSean C Gay, Ling Sun, Keiko Maekawa, et al.
Biochemical and Biophysical Research Communications|November 25, 2003
Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopyDmitri R Davydov, James R Halpert, Jean-Paul Renaud, et al.
The Journal of Biological Chemistry|January 28, 2006
Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modelingB K Muralidhara, Surendra Negi, Christopher C Chin, et al.
Biophysical Journal|April 14, 2016
Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR SpectroscopyDmitri R Davydov, Zhongyu Yang, Nadezhda Davydova, et al.
The Journal of Biological Chemistry|May 23, 2008
Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymesNuman Oezguen, Santosh Kumar, Aditya Hindupur, et al.
Biochemistry|May 26, 2004
An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryFDmitri R Davydov, Alexandra E Botchkareva, Santosh Kumar, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|January 8, 2004
Topological changes in the CYP3A4 active site probed with phenyldiazene: effect of interaction with NADPH-cytochrome P450 reductase and cytochrome b5 and of site-directed mutagenesisYoshitaka Yamaguchi, Kishore K Khan, You Ai He, et al.
Archives of Biochemistry and Biophysics|January 9, 2013
X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: insights into compensatory rearrangements of the binding pocketManish B Shah, Hyun-Hee Jang, Qinghai Zhang, et al.
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